Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis

Frontiers in Immunology
Barbara C MindtClaudia U Duerr

Abstract

Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they interact with and influence several immune and non-immune cell populations. Moreover, ILC2 are able to rapidly secrete large amounts of type 2 cytokines that can contribute to protective but also detrimental host immune responses depending on timing, location, and physiological context. Interestingly, ILC2, despite their scarcity, are the dominant innate lymphoid cell population in the lung, indicating a key role as first responders and amplifiers upon immune challenge at this site. In addition, the recently described tissue residency of ILC2 further underlines the importance of their respective microenvironment. In this review, we provide an overview of lung physiology including a description of the most prominent pulmonary resident cells together with a review of known and potential ILC2 interactions within this unique environment. We will further outline recent observations regarding pulmonary ILC2 during immune challenge including r...Continue Reading

References

Feb 1, 1979·The Journal of Allergy and Clinical Immunology·H S NoveyI D Wells
Jul 1, 1992·Journal of Applied Physiology·J Bastacky, J Goerke
Jan 1, 1988·Pediatric Pulmonology·M F DiMaioM Kattan
Apr 1, 1968·Journal of Ultrastructure Research·B Meyrick, L Reid
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·C M LillyJ M Drazen
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·R R MercerJ D Crapo
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·J E BoersF B Thunnissen
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M P SparrowP B McCray
Jan 5, 2000·Nature·S K YoshinagaG Senaldi
Jan 12, 2000·The Journal of Allergy and Clinical Immunology·A ShimbaraQ A Hamid
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M PuddicombeD E Davies
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Lara-MarquezB Karacay
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Kuniko MasuyamaKiyohisa Sekizawa
Feb 13, 2004·Nature·B MauroyB Sapoval
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·Lynne ReidHerbert Y Reynolds
May 10, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elina ToskalaCharles G Plopper
Nov 4, 2005·Proceedings of the American Thoracic Society·Bradley J Undem, Marian Kollarik
Jan 13, 2006·PLoS Medicine·Joseph P Mizgerd
Nov 15, 2006·International Immunology·Ulla-Angela TemannRichard A Flavell
Aug 25, 2007·Nature Reviews. Immunology·Nicholas D HuntingtonJames P Di Santo
Sep 15, 2007·Biochimica Et Biophysica Acta·Andrea Hartsock, W James Nelson
Nov 16, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Ernest CutzJie Pan
Apr 25, 2008·Current Protocols in Immunology·Mali CamberisJoseph Urban
May 9, 2008·Nature·Ross J MetzgerMark A Krasnow
Jun 24, 2008·Immunology and Allergy Clinics of North America·Kecia N Carroll, Tina V Hartert
Dec 10, 2008·The Journal of Allergy and Clinical Immunology·Zoulfia AllakhverdiGuy Delespesse
May 30, 2009·Age·Sian M Henson, Arne N Akbar
Mar 5, 2010·Nature·Daniel R NeillAndrew N J McKenzie
Apr 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lynn M Crosby, Christopher M Waters
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·April E PriceRichard M Locksley
Aug 12, 2010·Disease Models & Mechanisms·Jason R RockBrigid L M Hogan
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Keisuke ObokiSusumu Nakae
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gabriela KrastevaWolfgang Kummer

❮ Previous
Next ❯

Citations

Feb 23, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Alberta G A PaulJudith A Woodfolk
Jul 1, 2019·Biological Chemistry·Sofia Helfrich, Claudia U Duerr
May 29, 2019·International Immunology·Fumiyuki Sasaki, Takehiko Yokomizo
Sep 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Estefania ClaudioUlrich Siebenlist
Nov 30, 2019·Immunology·Stephanie C Ganal-Vonarburg, Claudia U Duerr
Jan 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oyebola O OyesolaElia D Tait Wojno
Jun 9, 2019·Science Immunology·Barbara C Mindt, Jörg H Fritz
May 14, 2020·Viruses·Allison E Norlander, R Stokes Peebles
Jul 10, 2020·European Journal of Clinical Investigation·Elisa GremeseGianfranco Ferraccioli
Aug 29, 2018·International Journal of Molecular Sciences·Gareth R WillisStella Kourembanas
Oct 7, 2018·Science Immunology·Tiffany Bouchery, Benjamin J Marsland
Jul 30, 2019·Frontiers in Immunology·Jessica G BorgerMargaret L Hibbs
Oct 9, 2018·Immunological Reviews·Christina StehleChiara Romagnani
Oct 18, 2019·Clinical Microbiology Reviews·Fariba M DonovanJohn N Galgiani
Dec 7, 2018·Current Opinion in Allergy and Clinical Immunology·Ichiro Tojima, Takeshi Shimizu
Mar 20, 2019·Frontiers in Immunology·Ben C L ChanChun K Wong
Jul 23, 2020·Drugs·John G RizkDonald N Forthal
Jul 14, 2020·Frontiers in Immunology·Anja Schulz-KuhntImke Atreya
Dec 10, 2020·Inflammatory Bowel Diseases·Luca MazzuranaJenny Mjösberg
Aug 8, 2020·Medical Hypotheses·Ajay Gupta, Kate Chander Chiang
Jan 12, 2021·Frontiers in Immunology·Arwa Abu KhweekProsper N Boyaka
Feb 9, 2021·BioMed Research International·Huihui ZhangYuanyi Peng
Nov 17, 2020·Frontiers in Immunology·Jill E WeatherheadDavid B Corry
Feb 28, 2021·Signal Transduction and Targeted Therapy·Bei WangDao Wen Wang
Sep 10, 2020·The Journal of Allergy and Clinical Immunology·Emily HowardOmid Akbari
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dan YangChuntao Liu
Apr 4, 2021·International Journal of Molecular Sciences·Baptiste GouyouMarcus Franz
May 7, 2021·Frontiers in Immunology·Wendy FonsecaCarrie-Anne Malinczak
Feb 7, 2019·Journal of Innate Immunity·Esmee K van der PloegRalph Stadhouders
Jun 19, 2021·The Journal of Allergy and Clinical Immunology·Doumet Georges HelouOmid Akbari
Nov 26, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L RayAndrij Holian

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cytokine & Growth Factor Reviews
Alessandra SorianiGiovanni Bernardini
Archivum Immunologiae Et Therapiae Experimentalis
Ananda S Mirchandani, Robert J Salmond
Methods in Molecular Biology
Claudia U Duerr, Jörg H Fritz
© 2022 Meta ULC. All rights reserved