Group A Rotavirus Detection and Genotype Distribution before and after Introduction of a National Immunisation Programme in Ireland: 2015-2019

Pathogens
Z YandleCillian F De Gascun

Abstract

Immunisation against rotavirus infection was introduced into Ireland in December 2016. We report on the viruses causing gastroenteritis before (2015-2016) and after (2017-2019) implementation of the Rotarix vaccine, as well as changes in the diversity of circulating rotavirus genotypes. Samples from patients aged ≤ 5 years (n = 11,800) were received at the National Virus Reference Laboratory, Dublin, and tested by real-time RT-PCR for rotavirus, Rotarix, norovirus, sapovirus, astrovirus, and enteric adenovirus. Rotavirus genotyping was performed either by multiplex or hemi-nested RT-PCR, and a subset was characterised by sequence analysis. Rotavirus detection decreased by 91% in children aged 0-12 months between 2015/16 and 2018/19. Rotarix was detected in 10% of those eligible for the vaccine and was not found in those aged >7 months. Rotavirus typically peaks in March-May, but following vaccination, the seasonality became less defined. In 2015-16, G1P[8] was the most common genotype circulating; however, in 2019 G2P[4] was detected more often. Following the introduction of Rotarix, a reduction in numbers of rotavirus infections occurred, coinciding with an increase in genotype diversity, along with the first recorded detectio...Continue Reading

References

May 1, 1996·Journal of Virological Methods·C T Tiemessen, M J Nel
Jul 24, 2001·The Pediatric Infectious Disease Journal·M LynchR I Glass
Aug 24, 2006·Journal of Medical Virology·Tomoichiro OkaNaokazu Takeda
Dec 10, 2009·Future Microbiology·Jelle MatthijnssensMarc Van Ranst
Mar 21, 2012·Archives of Virology·Jelle MatthijnssensReimar Johne
May 21, 2013·Journal of the Pediatric Infectious Diseases Society·Hoonmo L KooRobert L Atmar
Mar 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MatthijnssensUNKNOWN RotaBel study group
Mar 27, 2015·Emerging Infectious Diseases·Eszter Mihalov-KovácsKrisztián Bányai
Dec 22, 2015·Scientific Reports·Virginia E PitzerJelle Matthijnssens
Jan 23, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Daniel HungerfordMiren Iturriza-Gómara
Dec 10, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Krisztián BányaiFerenc Jakab
Sep 16, 2017·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maria Andersson, Magnus Lindh
Oct 27, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J KaplonA de Rougemont
Nov 13, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Corinna Pietsch, Uwe G Liebert
Apr 13, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Pietsch, U G Liebert
May 4, 2018·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
May 24, 2018·The Journal of Infectious Diseases·David I Bernstein

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Citations

Mar 2, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Z YandleC F De Gascun
Apr 14, 2021·Environmental Science and Pollution Research International·Eun Ju OhJae Kyung Kim
May 11, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nutthawadee JampanilPattara Khamrin
Aug 29, 2021·Pathogens·Celeste M Donato, Julie E Bines

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Datasets Mentioned

BETA
MT475885

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Excel
EuroRotaNet
ClustalW
RotaTeq
BLAST
MEGA X
TapeStation
Viia7
Sequence Detection
RotaC

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