PMID: 2186816Feb 1, 1990

Group A streptococcal polysaccharide--stimulator of nonspecific cytotoxic reaction in autologous system of spleen cells

Biulleten' eksperimental'noĭ biologii i meditsiny
E V GnezditskaiaL V Beletskaia

Abstract

p4 was shown the ability of group A streptococcal polysaccharide (A-PS) to stimulate nonspecific cytotoxic effect of spleen cells on autologous adherent cells (macrophages). The stimulating effect can be observed in vivo under the treatment of spleen cells with A-PS and any antigen (BSA, PPD, M-protein of group A streptococci). In the presence of antigen A-PS can induce nonspecific cytotoxic effect of normal spleen cells (mice CBA, BaLB/c) and of the mice with DHT and therefore these two immunologic phenomena do not depend on each other. Because A-PS has cross-reactive (CR) determinant with thymus epithelial antigen (factor), it can be assumed that via the CR determinant A-PS links with T-cells receptor for this thymus factor and thus realized the stimulating effect as it's functional analogue.

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·N H Ruddle

Related Concepts

Cross Reactions
Immunologic Tumoricidal Activities
Lymph Nodes
Macrophage
Mice, Inbred BALB C
Mice, Inbred CBA
Polysaccharides, Bacterial
Spleen
Bacteria, Flesh-Eating
Thymus Gland

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