PMID: 9542906May 23, 1998Paper

Group A streptococcal Vir types are M-protein gene (emm) sequence type specific

Journal of Clinical Microbiology
D GardinerK S Sriprakash

Abstract

The M-protein genes (emm genes) of 103 separate impetiginous Streptococcus pyogenes isolates were sequenced and the sequence types were compared to the types obtained by Vir typing. Vir typing is based on restriction fragment length polymorphism (RFLP) analysis of a 4- to 7-kb pathogenicity island encoding emm and other virulence genes. By using both HaeIII and HinfI to generate RFLP profiles, complete concordance between Vir type and emm sequence type was found. Comparison of the emm sequences with those in GenBank revealed new sequence types sharing less than 90% identity with known types. Diversity in the emm sequence was generated by corrected frameshift mutations, point mutations, and small in-frame mutations.

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Citations

Jun 11, 2004·Letters in Applied Microbiology·V SagarA Chakraborti
Apr 15, 2006·Journal of Korean Medical Science·Eun Ha KohSunjoo Kim
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard F FacklamBernard Beall
Aug 23, 2008·Journal of Medical Microbiology·Charmaine LloydThangam Menon
Aug 2, 2002·The Pediatric Infectious Disease Journal·Tania M Shelby-JamesJohn D Mathews
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nilay DeyHarpreet Vohra
Oct 18, 2008·Journal of Medical Microbiology·Bogdan Luca-HarariAftab Jasir
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alemseged AbdissaAbraham Aseffa
Sep 8, 2005·Journal of Clinical Microbiology·Wezenet Tewodros, Göran Kronvall
Nov 8, 2005·Journal of Clinical Microbiology·Ismail H SahandJosé Pontón

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