Group B streptococcal conjugate vaccine: a timely concept for which the time has come

Human Vaccines
Morven S Edwards

Abstract

Invasive disease due to group B Streptococcus (GBS) has been recognized as a threat to the health of pregnant women and their infants for almost half a century. Development of GBS vaccine candidates has progressed at an exemplary pace given lack of sponsorship by manufacturers. A trivalent or pentavalent vaccine will be required, and decisions must be made as to the criteria by which efficacy will be determined and the population in whom efficacy will be assessed. Concerns regarding durability of conjugate vaccine-derived immunity, pregnant women as a possible target group and regulatory issues required for licensing must be resolved if the prospect of impacting GBS disease burden through immunization is to become a reality.

Citations

Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olaf Schneewind, Dominique Missiakas
Jan 6, 2012·Journal of Clinical Microbiology·E R MartinsUNKNOWN Portuguese Group for the Study of Streptococcal Infections
Mar 5, 2009·Future Microbiology·Lakshmi Rajagopal
Dec 24, 2010·Women's Health·Zain A Al-SafiBernard Gonik
Sep 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Iwona SzymusikMiroslaw Wielgos
Dec 20, 2012·Expert Review of Vaccines·Romina Libster, Kathryn M Edwards
Feb 13, 2016·The Lancet Infectious Diseases·Reinhard Berner
Aug 11, 2010·The American Journal of the Medical Sciences·Michael S Bronze, James B Dale
Aug 30, 2013·Vaccine·Pierrette Melin, Androulla Efstratiou
Jun 26, 2012·Vaccine·Anita H J van den Biggelaar, William S Pomat
May 23, 2012·The Journal of Allergy and Clinical Immunology·John M KelsoDana Wallace
May 3, 2011·Gynécologie, obstétrique & fertilité·C Viala, P Deruelle
Mar 4, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jenny Fernebro
Jun 24, 2010·Clinics in Perinatology·Jennifer R Verani, Stephanie J Schrag
Jun 9, 2009·Pediatric Clinics of North America·Joyce M Koenig, William J Keenan
Feb 7, 2015·Journal of Paediatrics and Child Health·Danny Wh KoUNKNOWN GBS Study Group
Feb 12, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B LuH Wu
Oct 16, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L M LambertsenUNKNOWN Danish Streptococcal Surveillance Collaboration Group 2011
Jul 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica FabbriniImmaculada Margarit
May 3, 2014·Obstetrics and Gynecology·Jennifer R VeraniStephanie J Schrag
Jul 6, 2014·The Journal of Biological Chemistry·Francesco BertiImmaculada Margarit
Oct 18, 2011·Paediatric Drugs·Shruti Agrawal, Simon Nadel
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Filippo CarboniFrancesco Berti

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