PMID: 7545518May 1, 1995Paper

Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets

British Journal of Pharmacology
E VillamorJ Tamargo

Abstract

1. The effects of endotoxin (E. coli lipopolysaccharide, LPS) and heat inactivated group B Streptococcus (GBS) were studied on the contractile responses to noradrenaline (NA) in isolated pulmonary arteries and on the activity of the constitutive and inducible nitric oxide synthase (NOS) in lung fragments of neonatal piglets. 2. Short-term (< or = 5 h) incubation with LPS (1 micrograms ml-1) or GBS (3 x 10(7) colonies forming units ml-1) did not modify the vascular responsiveness to NA (10(-8) M-10(-4) M) in isolated intrapulmonary arteries. However, long-term incubation (20 h) with LPS or GBS produced a significant reduction in the maximal contractile responses and shifted the concentration-response curve for NA downwards. 3. Endothelium removal or the cyclo-oxygenase inhibitor meclofenamate (10(-5) M) did not affect the GBS- and LPS-induced hyporesponsiveness to NA. 4. The presence of the nitric oxide (NO) precursor, L-arginine (10(-5) M), 30 min prior to the contractility challenge increased the LPS- and GBS-induced pulmonary vascular hyporesponsiveness to NA. In contrast, the addition, prior to the challenge with NA, of the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) or coincubation with dexamethasone (...Continue Reading

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Citations

Dec 1, 1996·British Journal of Pharmacology·K M KengatharanC Thiemermann
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·K TrägerB Santak
Mar 22, 2013·Critical Care Medicine·Carmen MenendezFrancisco Perez-Vizcaino
Sep 2, 1998·The American Journal of Physiology·A M HoqueL C Fuchs
May 18, 1999·The American Journal of Physiology·Q Liu, J T Sylvester

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