PMID: 20632969Jul 17, 2010Paper

Group I metabotropic glutamate receptor signalling and its implication in neurological disease

CNS & Neurological Disorders Drug Targets
Fabiola M RibeiroStephen S G Ferguson

Abstract

Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to activation of a wide variety of signalling pathways. mGluRs couple to Gα(q/)₁₁ proteins, activating phospholipase Cβ1 resulting in both diacylglycerol and inositol-1,4,5-triphosphate formation followed by the activation of protein kinase C. In addition, mGluR activation can lead to modulation of a number of ion channels, such as different types of calcium and potassium channels. Group I mGluRs can also activate other downstream protein kinases, such as ERK1/2 and AKT, which are implicated in cellular growth, differentiation, and survival. Moreover, Group I mGluRs interact with a variety of different proteins that are important for the regulation of synaptic signalling, such as Homer and PDZ domain containing proteins, such as Tamalin. A role for mGluR1/5 in a number of disease states has also been proposed. As mGluR1/5 signal transduction is complex and involves multiple partners, a better understanding of alterations in mGluR signalling in brain disorders will be required in order to discern the molecular and cellular basis of these pathologies. This review will highlight recent findings concerning mGluR signaling alterations in brain patholog...Continue Reading

Citations

Oct 1, 2013·Frontiers of Medicine·Limin MaoJohn Q Wang
Dec 15, 2010·Molecular Neurobiology·Fabiola M RibeiroStephen S G Ferguson
Jul 21, 2012·The Journal of Pharmacology and Experimental Therapeutics·Cindy Achat-MendesRoger D Spealman
Mar 27, 2012·PloS One·Mohammed Akli AyoubLuba Kalaydjieva
Oct 25, 2013·International Journal of Biological Sciences·Stacey S Willard, Shahriar Koochekpour
Aug 29, 2013·International Journal of Biological Sciences·Stacey S Willard, Shahriar Koochekpour
Mar 19, 2014·Journal of Neural Transmission·Ivana R StojanovicSrdjan Ljubisavljevic
Feb 21, 2016·Neuropharmacology·Lumeng J YuSuzie Chen
Aug 15, 2014·Expert Opinion on Therapeutic Targets·Fabiola M RibeiroStephen Sg Ferguson
Aug 20, 2014·Journal of Nanobiotechnology·Kirstie SalinasFidel Santamaria
Jan 29, 2013·Neuroscience Letters·Jorge Mauricio Reyes-RuizRicardo Miledi
Oct 25, 2012·Drug Discovery Today·Vattoly J MajoJ S Dileep Kumar
Dec 20, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jenna M SullivanEvan D Morris
Apr 26, 2015·Biochemical and Biophysical Research Communications·David R GrubbElizabeth A Woodcock
Mar 21, 2013·Small GTPases·Jessica L Esseltine, Stephen S G Ferguson
Apr 18, 2015·Molecular Brain·Isabella M GuimaraesFabiola M Ribeiro
Dec 10, 2014·Current Opinion in Pharmacology·Sebastian H ScharfLothar Lindemann
Jun 11, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jinu LeeChul Hoon Kim
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Aldrin E MoleroMark F Mehler
Jun 25, 2016·BioMed Research International·Simona MagiVincenzo Lariccia
Jul 1, 2016·Journal of Sleep Research·David ElmenhorstAndreas Bauer
Oct 30, 2015·Science Translational Medicine·Li LiJoel T Dudley
Jul 14, 2017·Journal of Cell Science·Agnese De MarioMaria Catia Sorgato

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