Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits

Naunyn-Schmiedeberg's Archives of Pharmacology
Raghavendra Y NagarajaAxel Becker

Abstract

LY 367385 (mGluR1) and MPEP (mGluR5), which are group I metabotropic glutamate receptor (mGluR) antagonists, were used to investigate their effects on pentylenetetrazole (PTZ) seizures, kindling, and kindling-related learning deficits. Both substances showed anticonvulsant efficacy against seizures induced by lower doses of PTZ (40 mg/kg), but they were ineffective in counteracting seizures evoked by higher PTZ doses. When these substances were given in the course of kindling induction, LY significantly depressed the progression of kindled seizure severity. In contrast, MPEP was ineffective in this experiment. Treatment with either LY or MPEP did not modify the reaction to challenge dose of PTZ. Kindling results in a worsening of shuttle-box learning. LY improved shuttle-box learning when administered in the course of kindling development or when given prior to the learning experiment. This suggests protective and restorative effectiveness. In contrast, MPEP was only effective on the learning performance of kindled rats when given prior to the shuttle-box experiment, which demonstrates restorative effectiveness. Kindling is associated with an increase in glutamate binding. LY counteracted this increase whereas MPEP was ineffect...Continue Reading

Citations

Mar 3, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Susanne Ammon-TreiberAxel Becker
Oct 4, 2008·Cerebral Cortex·Li-Feng QiuZhi-Qi Xiong
Jan 5, 2007·Epilepsia·Markus SchillingAxel Becker
Aug 26, 2014·Pharmacological Reports : PR·Cecilia Zavala-TecuapetlaPavel Mareš
May 11, 2010·Epilepsy & Behavior : E&B·Marjan Nassiri-AslEsmail Abbasi
Jun 22, 2006·Epilepsy Research·Georgia M Alexander, Dwayne W Godwin
Jul 14, 2005·Neuropharmacology·Harlan E ShannonAnn E Kingston
Jun 12, 2013·Epilepsy & Behavior : E&B·Marjan Nassiri-AslParisa Bazahang
Mar 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shaaban A MousaMichael Schäfer
Jun 3, 2015·Bulletin of Experimental Biology and Medicine·V G BashkatovaH Prast
Feb 2, 2017·Iranian Red Crescent Medical Journal·Zahra FaridkiaMarjan Nassiri-Asl

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