Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro

European Journal of Pharmacology
D M O'LearyJ J O'Connor

Abstract

We have investigated the effect of a number of group I, II and III metabotropic glutamate (mGlu) receptor agonists and antagonists on paired pulse depression in the medial perforant path of the rat dentate gyrus in vitro. A triphasic pattern of a large depression at short intervals (10-50 ms), a reduction of this depression at intermediate intervals (50-200 ms) and again a large depression at late intervals (> 200 ms) was observed. The group I mGlu receptor agonist, (S)-3,5-dihydroxy phenylglycine ((S)-DHPG; 20 microM) had no significant effect on paired pulse depression at any interstimulus intervals. The mGlu receptor group II and III agonists, L-CCG-1 ((2S,3S,4S)-alpha-(carboxy-cyclopropyl)-glycine), DCG-IV ((2S,1'R,2'R,3'R)-2-2',3'-dicarboxy cyclopropylglycine), 1S,3R-ACPD (1S,3R-1-aminocyclopentate-1,3-dicarboxylic acid) and L-AP4 (L-2-amino-4-phosphono butyric acid) reduced paired pulse depression at interstimulus intervals of 200 ms or less. Application of the non specific mGlu receptor antagonist, MCPG (alpha-methyl carboxy-phenylglycine; 200 microM) completely inhibited the 1S,3R ACPD-induced reduction in paired pulse depression but was without effect on the L-AP4 response. The relatively specific group II antagonist M...Continue Reading

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Citations

Jun 14, 2000·Journal of Basic and Clinical Physiology and Pharmacology·H P FrizelleJ J O'Connor
May 25, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roberto De Pasquale, S Murray Sherman
Mar 1, 2013·Journal of Neurophysiology·Roberto De Pasquale, S Murray Sherman
Feb 25, 2003·British Journal of Pharmacology·Matthias LorezJames N C Kew
Feb 3, 2015·Journal of Neuroscience Research·Audrey M WallJohn J O'Connor
Apr 25, 2019·Environmental Science and Pollution Research International·Nasrin FazelianMahsa Rahimzadeh

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