Abstract
We have investigated the effect of a number of group I, II and III metabotropic glutamate (mGlu) receptor agonists and antagonists on paired pulse depression in the medial perforant path of the rat dentate gyrus in vitro. A triphasic pattern of a large depression at short intervals (10-50 ms), a reduction of this depression at intermediate intervals (50-200 ms) and again a large depression at late intervals (> 200 ms) was observed. The group I mGlu receptor agonist, (S)-3,5-dihydroxy phenylglycine ((S)-DHPG; 20 microM) had no significant effect on paired pulse depression at any interstimulus intervals. The mGlu receptor group II and III agonists, L-CCG-1 ((2S,3S,4S)-alpha-(carboxy-cyclopropyl)-glycine), DCG-IV ((2S,1'R,2'R,3'R)-2-2',3'-dicarboxy cyclopropylglycine), 1S,3R-ACPD (1S,3R-1-aminocyclopentate-1,3-dicarboxylic acid) and L-AP4 (L-2-amino-4-phosphono butyric acid) reduced paired pulse depression at interstimulus intervals of 200 ms or less. Application of the non specific mGlu receptor antagonist, MCPG (alpha-methyl carboxy-phenylglycine; 200 microM) completely inhibited the 1S,3R ACPD-induced reduction in paired pulse depression but was without effect on the L-AP4 response. The relatively specific group II antagonist M...Continue Reading
References
Apr 1, 1992·Neuron·I Aramori, S Nakanishi
Nov 12, 1992·Nature·I HerreroJ Sánchez-Prieto
Dec 1, 1992·Journal of Neurochemistry·V Boss, P J Conn
Dec 1, 1990·Trends in Pharmacological Sciences·D SchoeppF Sladeczek
Aug 2, 1990·European Journal of Pharmacology·Y NakagawaH Shinozaki
May 20, 1985·Brain Research·E W Harris, C W Cotman
Jul 1, 1973·The Journal of Physiology·T V Bliss, A R Gardner-Medwin
Jul 6, 1981·Brain Research·J F Koerner, C W Cotman
Oct 13, 1980·Brain Research·B L McNaughton
Aug 18, 1995·Neuroscience Letters·R E Brown, K G Reymann
Jan 1, 1995·Journal of Physiology, Paris·P E SchulzD Johnston
Feb 1, 1995·Neuropharmacology·T J BushellG L Collingridge
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Jan 1, 1995·Neuropharmacology·W B ThoresonR F Miller
Jan 1, 1993·Trends in Pharmacological Sciences·D D Schoepp, P J Conn
Feb 1, 1993·Neuroscience·E F BirseP J Roberts
Apr 28, 1995·Journal of Medicinal Chemistry·T KnöpfelH Allgeier
Mar 1, 1995·Neuroscience·T E Salt, S A Eaton
Apr 3, 1995·Brain Research·W B Thoreson, J S Ulphani
Sep 15, 1994·European Journal of Pharmacology·P CavanniF Ferraguti
Oct 1, 1994·Hippocampus·P G DiScenna, T J Teyler
Feb 10, 1994·Nature·J J O'ConnorR Anwyl
Jan 1, 1994·The European Journal of Neuroscience·I HerreroJ Sánchez-Prieto
Jul 1, 1994·British Journal of Pharmacology·D E JaneJ C Watkins
Sep 1, 1994·Trends in Pharmacological Sciences·J Watkins, G Collingridge
Jan 1, 1993·Neuropharmacology·Z A Bortolotto, G L Collingridge
Jan 1, 1993·Experimental Brain Research·J S Kahle, C W Cotman
Aug 1, 1995·Neuropharmacology·T KnöpfelF Gasparini
Aug 1, 1995·Neuropharmacology·A E KingstonD Lodge
Aug 1, 1995·Neuropharmacology·I BrabetJ P Pin
Jul 1, 1996·Journal of Neurochemistry·P J FlorT Knöpfel
Dec 1, 1995·British Journal of Pharmacology·L Eriksen, C Thomsen
Jun 1, 1996·British Journal of Pharmacology·D E Pellegrini-GiampietroF Moroni
Jan 5, 1996·Neuroscience Letters·A NekiN Mizuno
Oct 25, 1996·Science·T TakahashiK Onodera
Dec 1, 1996·Journal of Neurophysiology·T A MacekP J Conn
Jan 1, 1997·Molecular Pharmacology·J A SaugstadG L Westbrook
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
Citations
Apr 16, 2002·Synapse·A E BandrowskiJohn H Ashe
Mar 5, 2004·Neuropharmacology·Kurt RasmussenJim Vandergriff
Jul 28, 1999·European Journal of Pharmacology·A N Coogan, J J O'Connor
Sep 6, 2002·Neuropharmacology·Jin ZhaiEric S Nisenbaum
Feb 27, 2003·Neuropharmacology·H J Murray, J J O'Connor
Apr 28, 1999·Neuropharmacology·J Vandergriff, K Rasmussen
Jul 6, 2000·Neuroscience Letters·G Saleshando, J J O'Connor
Dec 12, 2001·Neuroscience·B Curran, J J O'Connor
Mar 22, 2002·Neuroscience·C CortiF Ferraguti
Jun 14, 2000·Journal of Basic and Clinical Physiology and Pharmacology·H P FrizelleJ J O'Connor
May 25, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roberto De Pasquale, S Murray Sherman
Mar 1, 2013·Journal of Neurophysiology·Roberto De Pasquale, S Murray Sherman
Feb 8, 2005·Neuropharmacology·Kurt RasmussenMatthew A Seager
Jul 19, 2005·Neuropharmacology·Katja Naie, Denise Manahan-Vaughan
Dec 26, 2001·Brain Research·Hai-Wei WangBarbara L Trommer
Feb 25, 2003·British Journal of Pharmacology·Matthias LorezJames N C Kew
Feb 3, 2015·Journal of Neuroscience Research·Audrey M WallJohn J O'Connor
Sep 24, 2013·Neurobiology of Disease·Audrey M WallJohn J O'Connor
Apr 25, 2019·Environmental Science and Pollution Research International·Nasrin FazelianMahsa Rahimzadeh
Aug 10, 1999·Anesthesia and Analgesia·H P FrizelleJ J O'Connor
Apr 9, 2016·The EMBO Journal·Sabine K SchmitzRuud F Toonen
Feb 25, 2003·Neuroreport·Jill V SteidlLinda M Boland