Group II introns break new boundaries: presence in a bilaterian's genome.

PloS One
Yvonne VallèsJeffrey L Boore

Abstract

Group II introns are ribozymes, removing themselves from their primary transcripts, as well as mobile genetic elements, transposing via an RNA intermediate, and are thought to be the ancestors of spliceosomal introns. Although common in bacteria and most eukaryotic organelles, they have never been reported in any bilaterian animal genome, organellar or nuclear. Here we report the first group II intron found in the mitochondrial genome of a bilaterian worm. This location is especially surprising, since animal mitochondrial genomes are generally distinct from those of plants, fungi, and protists by being small and compact, and so are viewed as being highly streamlined, perhaps as a result of strong selective pressures for fast replication while establishing germ plasm during early development. This intron is found in the mtDNA of an annelid worm, (an undescribed species of Nephtys), where the complete sequence revealed a 1819 bp group II intron inside the cox1 gene. We infer that this intron is the result of a recent horizontal gene transfer event from a viral or bacterial vector into the mitochondrial genome of Nephtys sp. Our findings hold implications for understanding mechanisms, constraints, and selective pressures that acco...Continue Reading

References

Apr 1, 1992·Trends in Genetics : TIG·C AndréV Walbot
Dec 11, 1991·Current Opinion in Genetics & Development·J D Palmer, J M Logsdon
Apr 1, 1968·Journal of Morphology·M E Clark
Sep 30, 1994·Journal of Molecular Biology·V KnoopA Brennicke
Jul 11, 1994·Nucleic Acids Research·T YamadaP Songsri
Jan 1, 1993·Annual Review of Biochemistry·A M Lambowitz, M Belfort
May 16, 1998·Genome Research·D GordonP Green
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Mar 5, 1999·Science·M W GrayB F Lang
Mar 31, 1999·Proceedings. Biological Sciences·M J van OppenD J Miller
Apr 2, 1999·Nucleic Acids Research·J L Boore
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J D PalmerK Song
Feb 27, 2001·Nucleic Acids Research·S Zimmerly Wu Xc
May 30, 2001·Trends in Genetics : TIG·L Bonen, J Vogel
Oct 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Natsuko KondoTakema Fukatsu
Nov 26, 2002·Nature·Gabriel M Belfort
Nov 28, 2002·Molecular Ecology·T L ShearerG Wörheide
Jan 10, 2003·Nucleic Acids Research·Lixin DaiSteven Zimmerly
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Jul 23, 2003·Critical Reviews in Biochemistry and Molecular Biology·Karola Lehmann, Udo Schmidt
Nov 25, 2003·Science·Michael Lynch, John S Conery
Jun 8, 2004·Bioinformatics·Stacia K WymanJeffrey L Boore
Dec 1, 2004·Annual Review of Genetics·Alan M Lambowitz, Steven Zimmerly
Jan 22, 2005·Trends in Genetics : TIG·Peik HaugenDebashish Bhattacharya
Aug 12, 2005·Cytogenetic and Genome Research·A R Robart, S Zimmerly
Mar 25, 2006·Science·Michael LynchSarah Schaack
May 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen L DellaportaBernd Schierwater
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mónica MedinaJeffrey L Boore
Aug 1, 2006·Trends in Microbiology·Mauricio H Pontes, Colin Dale
Sep 16, 2006·BMC Evolutionary Biology·Chagai RotDorothée Huchon

❮ Previous
Next ❯

Citations

Nov 10, 2013·Nucleic Acids Research·Srinivas SomarowthuAnna Marie Pyle
Feb 2, 2010·Nature Chemical Biology·Michael RoitzschAnna Marie Pyle
Apr 5, 2011·Journal of Molecular Cell Biology·Guenther Witzany
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alan M Lambowitz, Steven Zimmerly
Sep 21, 2010·BMC Evolutionary Biology·Amir SzitenbergDorothée Huchon
Dec 1, 2010·Applied and Environmental Microbiology·Fernando M García-RodríguezNicolás Toro
Nov 15, 2011·Nucleic Acids Research·Manuel A CandalesSteven Zimmerly
Sep 18, 2010·Cellular and Molecular Life Sciences : CMLS·Jessica Jacobs, Ulrich Kück
Feb 16, 2016·Wiley Interdisciplinary Reviews. RNA·Bonnie A McNeilSteven Zimmerly
May 8, 2010·Critical Reviews in Biochemistry and Molecular Biology·Anna Marie Pyle
Apr 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Steve J PerlmanBrent E Gowen
Nov 13, 2012·Molecular Phylogenetics and Evolution·Matthias BerntPeter F Stadler
Jan 8, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Xin ShenBin Liu
Aug 14, 2010·European Journal of Cell Biology·Jessica JacobsUlrich Kück
Aug 1, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stephanie Glanz, Ulrich Kück
Oct 1, 2011·The Plant Journal : for Cell and Molecular Biology·Stephanie GlanzUlrich Kück
Feb 28, 2015·Molecular Phylogenetics and Evolution·Yuanning LiKenneth M Halanych
Apr 5, 2008·Science·Navtej ToorAnna Marie Pyle
Nov 14, 2014·Journal of Molecular Evolution·Dirk ErpenbeckGert Wörheide
Jan 26, 2012·Wiley Interdisciplinary Reviews. RNA·Sandrine MoreiraGertraud Burger
Jun 29, 2017·Scientific Reports·Angelo F BernardinoKenneth M Halanych
May 14, 2020·F1000Research·Rafael Zardoya
Dec 15, 2015·BMC Evolutionary Biology·Dorothée HuchonTamar Feldstein
Aug 28, 2021·Cells·Jigeesha Mukhopadhyay, Georg Hausner

❮ Previous
Next ❯

Datasets Mentioned

BETA
EU293739

Methods Mentioned

BETA
PCR

Software Mentioned

CLUSTAL X
Phred
Modeltest
WU
Mfold
MacVector
PAUP
RAxML
BLAST
Consed

Related Concepts

Related Feeds

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.