Group II introns: versatile ribozymes and retroelements

Wiley Interdisciplinary Reviews. RNA
Bonnie A McNeilSteven Zimmerly

Abstract

Group II introns are catalytic RNAs (ribozymes) and retroelements found in the genomes of bacteria, archaebacteria, and organelles of some eukaryotes. The prototypical retroelement form consists of a structurally conserved RNA and a multidomain reverse transcriptase protein, which interact with each other to mediate splicing and mobility reactions. A wealth of biochemical, cross-linking, and X-ray crystal structure studies have helped to reveal how the two components cooperate to carry out the splicing and mobility reactions. In addition to the standard retroelement form, group II introns have evolved into derivative forms by either losing specific splicing or mobility characteristics, or becoming functionally specialized. Of particular interest are the eukaryotic derivatives-the spliceosome, spliceosomal introns, and non-LTR retroelements-which together make up approximately half of the human genome. On a practical level, the properties of group II introns have been exploited to develop group II intron-based biotechnological tools. WIREs RNA 2016, 7:341-355. doi: 10.1002/wrna.1339 For further resources related to this article, please visit the WIREs website.

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Citations

May 13, 2017·The International Journal of Biochemistry & Cell Biology·Matthew NguLinda Bonen
Oct 7, 2017·Genome Biology and Evolution·Eugene V Koonin, Kira S Makarova
Mar 14, 2019·Annals of the New York Academy of Sciences·Luis P Villarreal, Guenther Witzany
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Jun 22, 2021·Frontiers in Microbiology·Chase G MayersGeorg Hausner
Jun 23, 2021·Nucleic Acids Research·Félix LaRoche-JohnstonBenoit Cousineau

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