Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages

Journal of Neural Engineering
Jose Gomez-TamesAkimasa Hirata

Abstract

Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. We used a new inter-individual registration method that permitted the projection of computed electric fields (EFs) from individual realistic head models (n  =  18) to standard cerebellar template for the first time. Variations of the EF on the cerebellar surface were found to have standard deviations of up to 55% of the mean. The dominant factor that accounted for 62% of the variability of the maximum EFs was the skin-cerebellum distance, whereas the cerebrospinal fluid volume explained 53% of the average EF distribution. Despite the inter-individual variations, a systematic tendency of the EF hotspot emerges beneath the active electrode in group-level analysis. The hotspot can be adjusted by the electrode position so that the most effective stimulation is delivered to a group of subjects. Targeting specific cerebellar structures with ctDCS is not straightforward, a...Continue Reading

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Citations

Dec 5, 2019·Physics in Medicine and Biology·Jose Gomez-TamesShoogo Ueno
Jul 8, 2020·The Cerebellum·Frank Van OverwalleMaria Leggio
Feb 6, 2021·Scientific Reports·Martje G PaulyAnne Weissbach
Jan 10, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marom Bikson, Jacek Dmochowski
Feb 26, 2021·The Cerebellum·Jean-François NankooChristopher L Striemer
Aug 18, 2021·The Cerebellum·Gustavo V PonceDennis J L G Schutter

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