Group O blood donors in Iran: evaluation of isoagglutinin titers and immunoglobulin G subclasses.

Immunohematology
S ArabiM Mosaed

Abstract

This study aims to determine the most frequent titers of anti-A and anti-B (both presumed immunoglobulin [Ig]M and IgG) in Iranian group O blood donors and to compare these titer values with those found in other studies. In addition, alloantibody production and plasma levels of four IgG subclasses were compared between the high-titer and non-high-titer study groups. This study investigated anti-A and anti-B titers in 358 plasma samples. Based on these results, two study groups (high-titer and non-high-titer) were formed. Antibody detection tests were performed to detect unexpected antibodies to D, C, c, E, e, K, k, Fya, Fyb, Jka, Jkb, M, N, S, s, P1, Lea, and Leb. Four IgG subclasses were also evaluated through nephelometry assay. The most frequent titer obtained by room temperature and indirect antiglobulin tube tests was 256. The frequency of titers ≥512 was 31.5 percent. None of the cases showed unexpected RBC alloantibodies. IgG2 levels were significantly higher in the high-titer group. Evaluation of isoagglutinin titers in group O Iranian blood donors can provide insight into the frequency of isoagglutinin titers both within the Iranian population and as compared with other populations. A significant difference in IgG2 lev...Continue Reading

References

Jun 1, 1986·Journal of Clinical Pathology·L A Kay, D Locke
May 1, 1982·Annals of Internal Medicine·G R SiberB C Gorgone
Nov 29, 2001·Transfusion·W J Judd, UNKNOWN Scientific Section Coordinating Committee of the AABB
Feb 27, 2007·Transfusion·Marian T SullivanEdward L Wallace
Jul 18, 2008·Transfusion·Laura L CoolingRobertson D Davenport
May 5, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Janis R Hamilton
Mar 11, 2011·Transfusion·Aaron A R TobianKaren E King
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Natalia Dallaval Galvão de FrançaRafael Colella
Aug 16, 2016·Revista brasileira de hematologia e hemoterapia·Mariana Martins GodinLuci Maria SantAna Dusse
Mar 21, 2017·Asian Journal of Transfusion Science·Anita Amar TendulkarSanjay Velaye

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