Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro

Peptides
Han-Ning HuangJyh-Yih Chen

Abstract

Picornavirus is a highly contagious virus that usually infects cloven hoofed animals and causes foot-and-mouth disease. This disease is a major threat to livestock breeding worldwide and may lead to huge economic losses. Because effective vaccines or antiviral drugs remain unavailable, the search for new agents to combat FMDV infections is ongoing. Antimicrobial peptides are known to possess a broad range of biological activities, including antibacterial, antiviral, antitumor and immunomodulatory effects. In this work, we used a cell culture FMDV replication assay to evaluate several antimicrobial peptides for their ability to act as antiviral agents. We found that a synthesized form of the Epinephelus coioides antimicrobial peptide, epinecidin-1 (Epi-1), was effective at combatting FMDV. Epi-1 is known to have broad spectrum antimicrobial activity and low toxicity to normal eukaryotic cells, making it a good candidate for use as a therapeutic agent.The 50% cytotoxic concentration (CC50) for BHK-21 cells was 19.5 μg/ml for synthesized Epi-1, and the 50% effective concentration (EC50) for viral inhibition was 0.6 μg/ml. The selectivity index was 31.4, as calculated by the CC50/EC50 ratio. Furthermore, Epi-1 showed virucidal acti...Continue Reading

Citations

May 30, 2019·BMC Pharmacology & Toxicology·Alireza NeshaniKiarash Ghazvini
Oct 6, 2020·Journal of Veterinary Science·Xiuli LiangWenju Zhang
Nov 18, 2020·Antibiotics·Guihong PenJianhua Wang
May 31, 2021·Biochimica Et Biophysica Acta. General Subjects·Claudiane V AlmeidaMaria Lígia R Macedo
Dec 28, 2021·Critical Reviews in Food Science and Nutrition·Tiantian TianChao Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.