PMID: 9557789Apr 29, 1998Paper

Grover's-like disease in the setting of bone marrow transplantation and autologous peripheral blood stem cell infusion

The American Journal of Dermatopathology
J D HarvellW L White

Abstract

Four cases of a Grover's-like disease in patients with leukemia/lymphoma, who underwent high-dose chemotherapy and either allogeneic/autologous bone marrow transplantation or autologous stem cell infusion, are described. Three of four patients had fever prior to the onset of their rash. In addition to suprabasilar clefts, acantholysis, and dyskeratosis, typical of Grover's disease, there was a chemotherapeutic effect in the form of keratinocytes with atypical nuclei. So-called "starburst cells," which have been purported to be specific for high-dose etoposide (VP-16) therapy, were seen in two cases, but only one of these patients received etoposide. In one patient with clinical vesicles, direct immunofluorescence ruled out paraneoplastic pemphigus. In conjunction with 18 similar cases in the literature, the following conclusions were reached: (a) the pathogenesis probably involves the combined effects of fever (with sweating), occlusion, and chemo/radiation therapy; (b) no single chemotherapeutic agent can be consistently implicated; and (c) in addition to graft-versus-host disease, the eruption of lymphocyte recovery, and other cutaneous eruptions in the setting of bone marrow transplantation, the differential diagnosis includ...Continue Reading

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Citations

Feb 23, 1999·The American Journal of Dermatopathology·P R Cohen, R Kurzrock
Jan 16, 2013·Case Reports in Transplantation·Giovanbattista IppolitiRany Mahrous Haleem Saaleb
Jun 17, 2006·Journal of Cutaneous Pathology·Irene García-RíoAmaro García-Díez
Apr 20, 2006·The Journal of Dermatology·Fotini BoutliJean Kanitakis
Aug 24, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·G VillalonE Jorda
Aug 19, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Javier Bolaños-MeadeGeorgia B Vogelsang
Mar 22, 2014·Annals of Dermatology·Hye-Rim MoonKee Chan Moon
Oct 25, 2013·Clinical Nuclear Medicine·Hongyun June ZhuJames E McDonald
Jul 1, 2016·The Australasian Journal of Dermatology·Penny Poh Lu LimDavid Gottlieb
Aug 9, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Francesco BellinatoGiampiero Girolomoni
Jan 16, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Francesco BellinatoGiampiero Girolomoni
Sep 3, 2009·Archives of Pathology & Laboratory Medicine·Joshua Weaver, Wilma F Bergfeld
Nov 26, 1999·Journal of the American Academy of Dermatology·J M CasanovaA Alomar

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