PMID: 16200843Oct 5, 2005Paper

Growth and adult height in atypical coeliac patients, with or without growth hormone deficiency

Journal of Pediatric Endocrinology & Metabolism : JPEM
S SalardiDino Vaira

Abstract

To evaluate the effect of a gluten-free diet on growth and adult height, when available, in coeliac children without gastrointestinal symptoms. Sixty-one coeliac children without gastro-intestinal symptoms were included in the study. The age at diagnosis was 9.50 +/- 3.3 years. Thirty-eight had short stature at diagnosis (< 10th percentile) and 23 had normal stature. Thirty-seven reached adult height. After beginning the diet an increase in growth velocity was seen in 30 patients (responders) (20 with initial short stature), while in 31 patients (18 with short stature) there was no catch-up growth (non-responders). Bone age at diagnosis was significantly more delayed in the responders than in the non-responders. Target height was significantly higher in children with normal stature at diagnosis than those with short stature. Growth hormone (GH) deficiency was found and confirmed after 6-12 months of diet in 12 of the 38 patients (32%) with short stature. In the group of the 30 'short' patients who attained final height, target height was attained or improved in 12 patients (40%): in eight of the 16 (50%) responders and in four of the 14 (29%) non-responders; in eight (all responders) out of 22 (36%) without GH deficiency, and i...Continue Reading

References

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Citations

Jan 19, 2008·World Journal of Gastroenterology : WJG·Anna-Velia StaziBiagino Trinti
Aug 25, 2016·Journal of Pediatric Gastroenterology and Nutrition·Renata StawerskaAndrzej Lewiński
Sep 11, 2018·Endocrine Research·Marcella D WalkerMichael S Katz
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Diletta GiovenaleMauro Bozzola
Jun 19, 2008·The American Journal of Gastroenterology·Batia WeissYoram Bujanover
Mar 10, 2011·Pediatric Research·Jordan E PinskerMerrily Poth

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