PMID: 4365700Aug 1, 1973Paper

Growth-and density-dependent inhibition of deoxyglucose transport in Balb 3T3 cells and its absence in cells transformed by murine sarcoma virus

Proceedings of the National Academy of Sciences of the United States of America
S K Bose, B J Zlotnick

Abstract

The earliest measurable parameter that shows density-dependent inhibition is the uptake of [(3)H]deoxyglucose by Balb 3T3 cells. The rate decreases even during the exponential phase of growth and reaches a minimum, about 8- to 10-times lower than maximum, as the culture approaches the saturation density. Cells transformed by murine sarcoma virus fail to show either growth-dependent or density-dependent inhibition of deoxyglucose uptake. Treatment with dibutyryl cyclic AMP in the presence of theophylline results in premature cessation of growth and in an arrest in the decline of deoxyglucose transport. Culture in serum-deficient medium also produces rapid inhibition of growth at low cell density, but these cultures exhibit a markedly decreased rate of deoxyglucose uptake.

References

Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A W Hsie, T T Puck
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J R Sheppard
Sep 1, 1971·Biochemical and Biophysical Research Communications·J OttenI Pastan
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A GazdarY Ikawa
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S Venuta, H Rubin
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R W Holley
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·B M Sefton, H Rubin

Citations

Jan 1, 1977·Journal of Supramolecular Structure·G S Barsh, D D Cunningham
Apr 5, 1983·Biochimica Et Biophysica Acta·N D McKayN Rooke-Allen
Jul 1, 1975·Bio Systems·F A Alberghina
Dec 16, 1974·Biochimica Et Biophysica Acta·P G Plagemann, D P Richey
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R C Roa, S K Bose
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P CoffinoG M Tomkins
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S G Lee, F Lipmann
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S G Lee, F Lipmann
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J D Papamatheakis, D J Marciani
Apr 29, 1974·Biochimica Et Biophysica Acta·M Hatanaka
Feb 1, 1976·Experimental Cell Research·G S Johnson, J P Schwartz
Jan 1, 1976·Experimental Cell Research·E Walum, A Edström
Apr 4, 1978·Biochimica Et Biophysica Acta·J L Sullivan, A Debusk
Jun 15, 1976·Biochemical Pharmacology·G LipkinM E Knecht
Jul 16, 1986·Biochemical and Biophysical Research Communications·J A HamiltonS R Lingelbach
Feb 3, 1975·Biochemical and Biophysical Research Communications·K K Tsuboi, J C Petricciani
Sep 23, 1974·Biochimica Et Biophysica Acta·D PapahadjopoulosE Mayhew
Jul 5, 1974·Nature·S Bannai, J R Sheppard
Sep 1, 1981·Bioscience Reports·M J Morgan, P Faik
Jun 1, 1979·Journal of Cellular Physiology·L S Lee, I B Weinstein
Jun 1, 1976·Journal of Cellular Physiology·L Harel, M Jullien
Apr 1, 1982·Journal of Cellular Physiology·A H Romano, N D Connell
May 1, 1982·Journal of Cellular Physiology·A H Romano, N D Connell
Mar 1, 1983·Journal of Cellular Physiology·E Butler-Gralla, H R Herschman
Jul 1, 1979·Journal of Cellular Physiology·C P StannersJ W Pollard
Dec 1, 1976·Journal of Cellular Physiology·M J WeberD D LaRossa
Dec 1, 1976·Journal of Cellular Physiology·S J Atlas, S Lin

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.