May 28, 2014

Growth and differentiation of a long bone in limb development, repair and regeneration

Development, Growth & Differentiation
Shiro EgawaKoji Tamura

Abstract

Repair from traumatic bone fracture is a complex process that includes mechanisms of bone development and bone homeostasis. Thus, elucidation of the cellular/molecular basis of bone formation in skeletal development would provide valuable information on fracture repair and would lead to successful skeletal regeneration after limb amputation, which never occurs in mammals. Elucidation of the basis of epimorphic limb regeneration in amphibians would also provide insights into skeletal regeneration in mammals, since the epimorphic regeneration enables an amputated limb to re-develop the three-dimensional structure of bones. In the processes of bone development, repair and regeneration, growth of the bone is achieved through several events including not only cell proliferation but also aggregation of mesenchymal cells, enlargement of cells, deposition and accumulation of extracellular matrix, and bone remodeling.

Mentioned in this Paper

Bone Development
Amphibians
Amputated Structure (Morphologic Abnormality)
Aggregation
Extracellular Matrix
Chondrocyte
Entire Long Bone
Limb Structure
Cell Proliferation
Cell Differentiation Process

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