Growth and regression of vasculature in healthy and diabetic mice after hindlimb ischemia.
Abstract
The formation of vascular networks during embryogenesis and early stages of development encompasses complex and tightly regulated growth of blood vessels, followed by maturation of some vessels, and spatially controlled disconnection and pruning of others. The adult vasculature, while more quiescent, is also capable of adapting to changing physiological conditions by remodeling blood vessels. Numerous studies have focused on understanding key factors that drive vessel growth in the adult in response to ischemic injury. However, little is known about the extent of vessel rarefaction and its potential contribution to the final outcome of vascular recovery. We addressed this topic by characterizing the endogenous phases of vascular repair in a mouse model of hindlimb ischemia. We showed that this process is biphasic. It encompasses an initial rapid phase of vessel growth, followed by a later phase of vessel rarefaction. In healthy mice, this process resulted in partial recovery of perfusion and completely restored the ability of mice to run voluntarily. Given that the ability to revascularize can be compromised by a cardiovascular risk factor such as diabetes, we also examined vascular repair in diabetic mice. We found that parado...Continue Reading
References
Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)
Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice
Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation
Citations
Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia
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