Growth and repair of cartilage: organ culture system utilizing chondroprogenitor cells of condylar cartilage in newborn mice

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A WeissM Silbermann

Abstract

The zone of progenitor cells of mandibular condyles of neonatal mice was kept in an organ culture system for up to 8 days. Qualitative and quantitative determinations indicated a pronounced proliferative activity during the initial phases of the culture followed by a differentiation phase and the acquisition of typical hyaline cartilage. The mature hypertrophic chondrocytes were found to be surrounded by cartilage-specific macromolecules such as type II collagen, cartilage proteoglycans, and cartilage anchorin. The extracellular mineralization proceeded along matrix vesicles as is usually noted in vivo. A unique finding in this study was the observation that explants comprising cartilage progenitor cells and their adjacent extracellular matrix succeeded in repairing the damaged condylar in vitro.

References

Jan 1, 1979·Biology of the Neonate·M Silbermann, E Livne
Jun 1, 1978·Nature·J Folkman, A Moscona
Oct 1, 1987·Collagen and Related Research·G MaorM Silbermann
Jul 1, 1973·American Journal of Orthodontics·M C Meikle
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·M StokerV Waxman
Aug 1, 1984·European Journal of Biochemistry·H von der MarkR Timpl

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Citations

Feb 20, 2010·Biomechanics and Modeling in Mechanobiology·Marnie M SaundersAmanda F Taylor
Feb 13, 2001·Experimental Gerontology·A Globerson
Mar 1, 1996·Osteoarthritis and Cartilage·C T BassleerJ Y Reginster
Nov 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R Shurtz-SwirskiM Silbermann
Jan 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gayani SenevirathneNeil H Shubin
Nov 1, 1990·Journal of Dental Research·F E EngelB D Boyan

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