Growth and tissue accretion rates of swine expressing an insulin-like growth factor I transgene

Animal Biotechnology
V G PurselRobert J Schwartz

Abstract

The goal of this research was to determine whether directing expression of an insulin-like growth factor I (IGF-I) transgene specifically to striated muscle would alter the growth characteristics in swine. Transgenic pigs were produced with a fusion gene composed of avian skeletal alpha-actin regulatory sequences and a cDNA encoding human IGF-I. Six founder transgenic pigs were mated to nontransgenic pigs to produce 11 litters of G1 transgenic and sibling control progeny. Birth weight, weaning weight, and proportion of pig survival did not differ between transgenic and control pigs. The ADG of pigs as they grew incrementally from 20 to 60 kg, 60 to 90 kg, and 90 to 120 kg, respectively, did not significantly differ between transgenic and control pigs. Efficiency of feed utilization (gain:feed) was also similar for transgenic and control pigs. Plasma IGF-I and porcine growth hormone (pGH) concentrations were determined at 60, 90, and 120 kg body weight. Plasma IGF-I concentrations were 19% higher in transgenic gilts than control gilts and 11.1% higher in transgenic boars than control boars (P=0.0005). Plasma IGF-I concentrations for boars were also higher than for gilts (P=0.0001). At 60, 90, and 120 kg body weight each pig was ...Continue Reading

References

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Citations

Feb 6, 2010·Transgenic Research·Kathryn A JacksonElizabeth A Maga
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·L B McNamaraP G Lawlor
Apr 5, 2005·Nature Biotechnology·Robert J WallHarold W Hawk
Feb 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert H DevlinBenjamin Goh
May 16, 2014·American Journal of Respiratory Cell and Molecular Biology·Eoin P JudgeShirley O'Dea
Feb 13, 2016·The Journal of Dairy Research·C Bruce A WhitelawChris Proudfoot
Nov 12, 2014·Annual Review of Animal Biosciences·Lydia C GarasElizabeth A Maga
Sep 10, 2005·Trends in Biotechnology·Elizabeth A Maga
Mar 17, 2010·Journal of Animal Science·S C FahrenkrugB P Glenn
Feb 16, 2010·Journal of Animal Science·E A Maga, J D Murray
Jul 18, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bhanu P TeluguChi-Hun Park
Jun 15, 2012·Reproduction in Domestic Animals = Zuchthygiene·C GalliG Lazzari
Apr 13, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·L TemmermanN Rosenthal

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Methods Mentioned

BETA
transgenic
biopsies
X-ray
blood collection

Software Mentioned

SAS System
SAS

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