PMID: 7403688Jan 1, 1980Paper

Growth and treatment of B 16 melanoma in hyperglycemic mice

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
J PavelićK Pavelić

Abstract

Melanoma B-16 grew slowly in mice with hyperglycemia induced by alloxan, glucagon, or glucose. The mechanism of retarded tumor growth is different and depends on the origin of hyperglycemia. The concentration of immunoreactive insulin in blood of mice with melanoma and in the tumor tissue is increased in nondiabetic as well as in diabetic mice. The chemotherapy of melanoma in diabetic mice is as effective as in nondiabetic mice whereas immunotherapy in diabetic mice is not effective. Combined chemoimmunotherapy of melanoma in diabetic mice is more effective than either therapy alone only when mice are given a daily dose of insulin.

References

Sep 28, 1978·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·K Pavelic, I Hrsak
Jun 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Pavelić, M Slijepcević
Sep 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K PavelićJ Pavelić
Jan 1, 1972·Advances in Cancer Research·V S Shapot
Jan 21, 1969·Biochimica Et Biophysica Acta·R W Turkington, O T Ward
Jan 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Pavelić, K Pavelić
Jan 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K Pavelić, J Pavelić
Jan 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HYVARINEN, E A NIKKILA

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Citations

Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·K PavelićJ Pavelić
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberM F Sorrell
Jun 15, 1982·International Journal of Cancer. Journal International Du Cancer·S Vuk-PavlovićK Pavelić

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