Growth arrest-specific 6 and cardiometabolic risk factors in patients with psoriasis

Cardiovascular Therapeutics
Murat SunbulMehmet Agirbasli

Abstract

An increased risk for cardiovascular disease with psoriasis has been reported. Growth Arrest-Specific 6 (GAS6) amplifies pro-inflammatory endothelial cell activation via TAM receptors. However, it also inhibits inflammation by multiple mechanisms including phagocytosis. The objective of this study was to investigate whether plasma GAS6 levels are associated with conventional cardiometabolic (CM) risk factors in patients with psoriasis. Forty patients diagnosed with psoriasis (22 male, mean age: 43.3 ± 13.8 years) and 40 age-/sex-matched healthy controls (22 male, mean age: 39.3 ± 8.9 years) were included in the study. CM risk factors (hypertension, hyperlipidemia, diabetes mellitus, and cigarette smoking) were identified. GAS6 levels were measured by ELISA. There were no significant differences between the plasma GAS6 levels of patients with psoriasis compared to the control group (6.6 ± 2.0 ng/mL, 7.6 ± 2.8 ng/mL, respectively, P > 0.05). However, GAS6 levels of patients with psoriasis having a smoking history (n = 11) were significantly lower than both patients with psoriasis who had no smoking history (n = 29) and controls (5.5 ± 1.7 ng/mL, 6.9 ± 1.9 ng/mL, 7.6 ± 2.8 ng/mL, respectively, P < 0.05). Similarly, psoriasis patie...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Dec 24, 2002·Current Opinion in Immunology·Greg Lemke, Qingxian Lu
Dec 18, 2003·Clinical and Experimental Immunology·J E GudjonssonH Valdimarsson
Jun 8, 2004·Current Drug Targets. Inflammation and Allergy·Luigi Naldi
Dec 21, 2004·Seminars in Arthritis and Rheumatism·Mike J PetersMichael T Nurmohamed
Dec 24, 2005·Critical Care Medicine·Delphine BorgelJean-Luc Diehl
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Jan 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Sébastien GibotPierre-Edouard Bollaert
Feb 23, 2007·Nature·Michelle A LowesJames G Krueger
Apr 19, 2008·Nature Reviews. Immunology·Greg Lemke, Carla V Rothlin
May 23, 2008·Clinical Journal of the American Society of Nephrology : CJASN·John Danziger
Oct 9, 2008·Thrombosis and Haemostasis·Laura Fernández-FernándezPablo García de Frutos
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Apr 27, 2010·Dermatologic Therapy·Gino A VenaNicoletta Cassano
Feb 8, 2011·Clinical Cardiology·Chandrasekar PalaniswamyStephen J Peterson
Apr 8, 2011·Journal of General Internal Medicine·Rita V PatelRobert S Kirsner
Jul 12, 2011·Journal of the American Academy of Dermatology·Jonathan ShapiroMichael David
Jul 27, 2011·The American Journal of Medicine·Nehal N MehtaJoel M Gelfand
Nov 11, 2011·Thrombosis and Haemostasis·Sylvain ClauserDelphine Borgel
Nov 25, 2011·The Journal of Investigative Dermatology·Sinéad M LanganJoel M Gelfand
Apr 21, 2012·Advances in Nutrition·Sandrine LauranceMark D Blostein
Feb 1, 2013·Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır·Emre Refik AltekinErkan Alpsoy
Apr 10, 2013·Current Pharmaceutical Design·Murat Sunbul, Mehmet Agirbasli
May 21, 2013·Journal of Dermatological Science·András SzászIstván Nagy
May 23, 2014·Inflammatory Bowel Diseases·Carla V RothlinSourav Ghosh
Mar 26, 2015·Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology·Fikriye UrasAhmet Muzaffer Demir

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Citations

Mar 25, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emel Eksi AlpFikriye Uras
Apr 14, 2019·Cardiovascular Research·Lucy McShanePasquale Maffia
Feb 6, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Zeynep CagmanFikriye Uras

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