Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis

Neuropathology and Applied Neurobiology
C E TeunissenL Bö

Abstract

Axonal damage in multiple sclerosis (MS) is correlated to disease progression. Early axonal damage may be compensated for by regenerative processes. Growth-associated protein 43 (GAP-43) is a marker for axonal growth and synaptogenesis in various neurodegenerative diseases. We investigated the expression of GAP-43 in 48 MS grey and white matter lesions of different stages. Decreased GAP-43 expression was found in 74% of the white matter lesions, independent of the lesion stage. In 19 out of 35 white matter lesions, areas of increased GAP-43 expression were present immediately adjacent to the lesions. Increased or unaltered expression was observed in remyelinated lesions. GAP-43 was expressed in neurofilament-positive structures. GAP-43 expression appeared unchanged in grey matter lesions. Macrophages were present in the areas of changed GAP-43 expression. cerebrospinal fluid GAP-43 levels were negatively correlated with magnetic resonance imaging measures of whole-brain atrophy (r = -0.30). In conclusion, these results indicate that decreased GAP-43 immunopositivity reflects axonal damage in MS lesions, which may again be reflected in decreased cerebrospinal fluid levels. The increased levels of GAP-43 in remyelinated or nondem...Continue Reading

References

Feb 1, 1995·The Journal of Cell Biology·L Aigner, P Caroni
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·N I Perrone-BizzozeroR L Neve
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Jan 9, 1999·European Journal of Pharmacology·J J HensP N De Graan
Sep 11, 1999·Annals of Neurology·L W WhitneyW E Biddison
Dec 29, 1999·Nature Medicine·D PittC S Raine
May 29, 2000·Brain : a Journal of Neurology·A BitschW Brück
Jun 1, 2000·Journal of the Neurological Sciences·C I SzeL J Martin
Jul 7, 2000·Neuroreport·H YamanouchiY Nakazato
Mar 7, 2001·Journal of the Neurological Sciences·G MancardiA Uccelli
Sep 11, 2001·The American Journal of Pathology·I MedanaH Neumann
Sep 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nina IrwinLarry I Benowitz
Sep 24, 2002·Brain : a Journal of Neurology·Tanja KuhlmannWolfgang Brück
Oct 23, 2002·Journal of Neuroscience Research·Nozomu Mori, Hiroshi Morii
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Feb 1, 2003·Journal of the Neurological Sciences·C BjartmarB D Trapp
Feb 13, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gareth R JohnCelia F Brosnan
Feb 19, 2003·Nature Genetics·Corinna Lappe-SiefkeKlaus-Armin Nave
Mar 6, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Benjamin TurnerLance D Blumhardt
Aug 21, 2003·Multiple Sclerosis : Clinical and Laboratory Research·L BøS J Mørk
Sep 3, 2003·Nature Reviews. Neuroscience·Marie T Filbin
Jan 22, 2004·Nature Reviews. Neuroscience·Geoffrey Raisman
Feb 27, 2004·Occupational and Environmental Medicine·A Reckner OlssonG Wingren
Mar 11, 2004·The European Journal of Neuroscience·Sara Gianola, Ferdinando Rossi
Oct 20, 2004·The Journal of Experimental Medicine·Martin KerschensteinerMartin E Schwab

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Citations

Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna Letizia Allegra MascaroFrancesco S Pavone
Mar 5, 2013·Journal of Neuroinflammation·Daphne Y S VogelChristine D Dijkstra
Sep 2, 2014·Journal of Neuroimmunology·Sharmilee GnanapavanGavin Giovannoni
Sep 12, 2012·Journal of Neuropathology and Experimental Neurology·Paschalis TheotokisNikolaos Grigoriadis
Nov 19, 2011·Multiple Sclerosis International·Irena Dujmovic
Jan 20, 2007·Progress in Neurobiology·Ferdinando RossiLuigi Corvetti
May 23, 2013·Proteomics·Anna HäggmarkPeter Nilsson
Oct 31, 2014·Annals of Clinical and Translational Neurology·Zhong YingWilliam Bingaman
Aug 26, 2014·BioMed Research International·Aileen P PattersonReuben Saba
Nov 23, 2019·Scientific Reports·Åsa SandeliusJan Lycke
Aug 11, 2018·Multiple Sclerosis Journal - Experimental, Translational and Clinical·U RotK Blennow

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