Growth characteristics of human adenoviruses on porcine cell lines

Virology
Nadine GriescheBarbara Biere

Abstract

Human adenoviruses (hAdV) have been recognized as a highly prevalent virus family causing severe disease in immunocompromised patients. In xenotransplantation the xenograft therefore will be exposed to these viruses, which in case of its infection might contribute to posttransplant complications. To evaluate the susceptibility of porcine cells for hAdV, we infected the porcine cell line POEK with seven serotypes representing all six hAdV species. Additionally, a second porcine cell line (ST) was infected with two serotypes. Viral replication of serotypes varied: porcine cells were fully permissive for serotypes 1, 4 and 17, semi-permissive for 11 and 21, and non-permissive for 31 and 40. Furthermore, we demonstrated the interaction of serotype 1 with the porcine homologue of the coxsackie-adenovirus receptor, the receptor used by many hAdV serotypes for cell attachment. Thus, various adenovirus types of different hAdV species may be capable of infecting different porcine tissue types.

References

Oct 1, 1994·Veterinary Immunology and Immunopathology·D H Sachs
Mar 1, 1997·Nature Medicine·C PatienceR A Weiss
Jun 1, 1997·International Immunology·K ToyomuraT Kinoshita
Jan 1, 1997·British Medical Bulletin·J van den Bogaerde, D J White
May 23, 1998·Annual Review of Immunology·H Auchincloss, D H Sachs
Apr 27, 2000·Molecular Medicine Today·W H Günzburg, B Salmons
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·C J CohenJ M Bergelson
Dec 26, 2001·The Journal of General Virology·O Brad SpillerB Paul Morgan
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A C LankesterA C M Kroes
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco W SchilhamMaarten J van Tol
Feb 1, 2003·The Lancet Infectious Diseases·Tony WallsDelane Shingadia
Apr 16, 2003·Journal of Medical Virology·Albert HeimPatricia Pring-Akerblom
Nov 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·L F GUERIN, M M GUERIN
Jan 6, 1962·Nature·A O BETTSZ PAGE
Oct 21, 2003·Nature Medicine·Anuj GaggarAndré Lieber
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jay A Fishman, Clive Patience
Apr 22, 2005·Dermatologic Therapy·Priya VenkatesanSarah A Myers
Jun 14, 2005·Clinical Chemistry·Barbara ChmielewiczHeinz Ellerbrok
Jun 30, 2005·Current Opinion in Infectious Diseases·Deepali Kumar, Atul Humar
Sep 15, 2005·Journal of Virology·Yuanming Zhang, Jeffrey M Bergelson
Mar 16, 2007·Journal of Virology·Morris Saffold JonesDavid P Schnurr

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Citations

Jan 12, 2010·Current Opinion in Organ Transplantation·Anne-Laure Millard, Nicolas J Mueller
Jul 10, 2008·Xenotransplantation·Reto M Baertschiger, Leo H Buhler
Feb 13, 2010·Xenotransplantation·Anne Laure Millard, Nicolas J Mueller
Mar 18, 2011·Veterinary Pathology·S KnaufK Mätz-Rensing
Jul 12, 2019·Frontiers in Microbiology·Joseph OngrádiDharam V Ablashi
Mar 31, 2010·Current Opinion in Organ Transplantation

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