Growth cone chemotaxis

Trends in Neurosciences
Duncan MortimerG J Goodhill

Abstract

Wiring up the nervous system depends on the precise guidance of axonal growth cones to their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth cones detect and follow molecular gradients. Although recent work has uncovered many of the molecules involved in this process, the mechanisms underlying chemotactic axon guidance are still unclear. Here we compare growth cones with neutrophils and Dictyostelium discoideum, systems for which a clear conceptual framework for chemotaxis has recently emerged. This analogy suggests particular ways in which the three key steps of directional sensing, polarisation and motility might be implemented in chemotaxing growth cones.

References

Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Apr 10, 1999·Molecular Biology of the Cell·G ServantH R Bourne
Apr 30, 1999·Science·C A Parent, P N Devreotes
Mar 14, 2002·Current Opinion in Cell Biology·Orion D Weiner
May 3, 2002·Nature·Guo-li MingMu-ming Poo
Dec 10, 2002·Science·Barry J Dickson
Apr 4, 2003·The Journal of Biological Chemistry·Peter Devreotes, Chris Janetopoulos
Nov 5, 2003·Journal of Neurobiology·Feng-Quan Zhou, Christopher S Cohan
Dec 20, 2003·Nature Reviews. Neuroscience·Kun-Liang Guan, Yi Rao
Mar 24, 2004·Current Opinion in Cell Biology·Carole A Parent
Apr 7, 2004·Neuron·Carmine GuirlandJames Q Zheng
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Peter J M Van Haastert, Peter N Devreotes
Oct 13, 2004·Neural Computation·Geoffrey J GoodhillJeffrey S Urbach
Dec 22, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Søren S L Andersen
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tatsuo Shibata, Koichi Fujimoto
Jan 5, 2005·Biochemical and Biophysical Research Communications·Masashi FujitaniToshihide Yamashita
Aug 19, 2005·Nature·Karen Y WuSamie R Jaffrey
Sep 13, 2005·Molecular and Cellular Neurosciences·Michael E WardYi Rao
Jan 24, 2006·Nature Reviews. Neuroscience·Timothy M Gomez, James Q Zheng
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie Woo, Timothy M Gomez
Feb 28, 2006·Nature Cell Biology·Nelson A MedeirosPaul Forscher
Jun 30, 2006·Journal of Neurochemistry·Hiroyuki Kamiguchi
Sep 19, 2006·Nature Neuroscience·Kin-Mei LeungChristine E Holt
Dec 13, 2006·Nature Neuroscience·Takuro TojimaHiroyuki Kamiguchi
Mar 21, 2007·PLoS Computational Biology·Matthew Onsum, Christopher V Rao
Apr 10, 2007·Biophysical Journal·Masahiro Ueda, Tatsuo Shibata
Apr 26, 2007·Bulletin of Mathematical Biology·Alexandra JilkineLeah Edelstein-Keshet
May 23, 2007·The Journal of Cell Biology·Ineke Keizer-GunninkPeter J M Van Haastert
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter W GrabhamRichard B Vallee
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cédric BouziguesMaxime Dahan
Jul 31, 2007·The EMBO Journal·Andrew C Lin, Christine E Holt
Aug 7, 2007·PLoS Computational Biology·Burton W Andrews, Pablo A Iglesias

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Citations

Jun 28, 2014·Trends in Neurosciences·Daniel J SutherlandGeoffrey J Goodhill
Jan 24, 2014·Chemistry and Physics of Lipids·Joseph J Falke, Brian P Ziemba
Jul 30, 2014·Neuroscience Research·Michihiro Igarashi
Jan 1, 2015·Journal of the Royal Society, Interface·H NguyenG J Goodhill
Apr 18, 2009·Nature Reviews. Molecular Cell Biology·Laura Anne Lowery, David Van Vactor
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Duncan MortimerGeoffrey J Goodhill
Jul 1, 2009·PLoS Biology·Erik A Lundquist
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Duncan MortimerGeoffrey J Goodhill
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Robert R Kay, Christopher R L Thompson
Dec 21, 2010·Molecular Biology of the Cell·Ming TangPeter Devreotes
Oct 2, 2013·The Journal of Cell Biology·Toshiaki ShigeokaChristine E Holt
May 7, 2013·European Biophysics Journal : EBJ·Philipp RauchJosef A Käs
Nov 26, 2010·Neural Computation·Duncan MortimerGeoffrey J Goodhill
Jul 8, 2011·Neural Computation·Elizabeth M ForbesGeoffrey J Goodhill
Jan 24, 2013·Neural Computation·Jiajia YuanGeoffrey J Goodhill
Nov 21, 2013·European Journal of Cell Biology·Juan P ZaninRoberto A Rovasio
Feb 4, 2010·The Journal of Cell Biology·Atsushi TamadaHiroyuki Kamiguchi
Nov 11, 2014·Analytical Chemistry·Rong-Rong XiaoWei-Hua Huang
Mar 25, 2011·Medical Hypotheses·Min FangXue-Feng Wang
Mar 8, 2011·Molecular and Cellular Neurosciences·Andrew W ThompsonGeoffrey J Goodhill
Dec 29, 2009·Journal of Neuroscience Methods·Carmen Haines, Geoffrey J Goodhill
Jun 2, 2009·Brain Research Bulletin·Gabriel ScicoloneNéstor Gabriel Carri
Oct 28, 2008·Trends in Cell Biology·Christopher C Quinn, William G Wadsworth
May 20, 2015·Scientific Reports·Seongjun ParkPolina Anikeeva
Jul 14, 2009·Developmental Neurobiology·Jummi LaishramVincent Torre
Aug 26, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cristina Sánchez-Camacho, Paola Bovolenta
May 10, 2012·Journal of Cellular Physiology·Bing ZhengHuanxiang Zhang
Mar 2, 2016·Trends in Neurosciences·Geoffrey J Goodhill
Apr 9, 2016·Trends in Immunology·Sussan NoursharghBeat A Imhof
Mar 17, 2016·European Journal of Cell Biology·Ezequiel J TolosaRoberto A Rovasio
Jul 6, 2014·Journal of Theoretical Biology·H NguyenG J Goodhill
Jan 6, 2009·Developmental Biology·James Allen, John K Chilton

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