PMID: 8979812Jan 1, 1996Paper

Growth cone dynamics and activity-dependent processes in neuronal network development

Progress in Brain Research
J van PeltM A Corner

Abstract

Many structural and functional properties of neuronal networks find their origin in the dynamic behavior of growth cones during development. The variation in dendritic morphologies can be traced back to random branching of growth cones. Segment length characteristics arise under random branching and steady growth cone propagation. Delayed outgrowth, as a result of competition between growth cones after splitting, is hypothesized to explain different lengths of paired terminal segments in Purkinje cells. The implications of activity-dependent neurite outgrowth were studied using an outgrowth function based on the theory of Kater et al. (1988, 1990). This theory embodies a homeostatic principle, according to which a neuron adapts its neuritic field so as to maintain a certain level bioelectric activity. It is shown that such homeostasis has many implications for neuromorphogenesis and network formation, as it may underlie phenomena such as overshoot during development, size differences among cells, differentiation between excitatory and inhibitory cells and compensatory sprouting. Finally, function-dependent regulation of development involves physiological as well as morphological variables. For instance, activity dependent regul...Continue Reading

Citations

Jul 12, 2005·Annual Review of Biomedical Engineering·Susan Maskery, Troy Shinbrot
Aug 11, 2007·Bioscience, Biotechnology, and Biochemistry·Noriyuki Yanaka
Jul 20, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R SegevE Ben-Jacob
Feb 4, 2009·Journal of Neurochemistry·Grit SchaarschmidtHartmut Schmidt
Jul 26, 2016·Frontiers in Neuroanatomy·Michael Fauth, Christian Tetzlaff
Feb 16, 2005·FEBS Letters·Brad BryanMingyao Liu
Mar 21, 2006·Neurochemistry International·Jeffrey D EricksonEberhard Weihe

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