Growth cone pathfinding: a competition between deterministic and stochastic events

BMC Neuroscience
Susan MaskeryTroy Shinbrot

Abstract

Growth cone migratory patterns show evidence of both deterministic and stochastic search modes. We quantitatively examine how these two different migration modes affect the growth cone's pathfinding response, by simulating growth cone contact with a repulsive cue and measuring the resultant turn angle. We develop a dimensionless number, we call the determinism ratio Psi, to define the ratio of deterministic to stochastic influences driving the growth cone's migration in response to an external guidance cue. We find that the growth cone can exhibit three distinct types of turning behaviors depending on the magnitude of Psi. We conclude, within the context of these in silico studies, that only when deterministic and stochastic migration factors are in balance (i.e. Psi ~ 1) can the growth cone respond constructively to guidance cues.

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Citations

Sep 28, 2010·Annals of Biomedical Engineering·A G VoyiadjisT Shinbrot
Mar 11, 2011·Bulletin of Mathematical Biology·Yanthe E PearsonDonald A Drew
Mar 12, 2011·Journal of Neurotrauma·Andrew G VoyiadjisTroy Shinbrot
Nov 23, 2006·BMC Neuroscience·Bruce P Graham, Arjen van Ooyen
Jul 12, 2005·Annual Review of Biomedical Engineering·Susan Maskery, Troy Shinbrot
Apr 13, 2011·Journal of Biomedical Materials Research. Part a·In Hong YangChia-Chi Ho
Apr 6, 2007·Journal of Neural Engineering·D R NisbetJ S Forsythe
Apr 3, 2021·Physical Review Letters·Hadrien OliveriAlain Goriely
Nov 27, 2004·Trends in Cell Biology·Narat J Eungdamrong, Ravi Iyengar
Feb 15, 2008·Developmental Biology·Carlos E Caicedo-Carvajal, Troy Shinbrot
Aug 19, 2009·Biophysical Journal·Troy ShinbrotRamsey Foty
Aug 5, 2009·Biophysical Journal·Joanne M BrittoSeong-Seng Tan
Jul 2, 2021·Advanced Healthcare Materials·Sitara VedaramanLaura De Laporte
Aug 7, 2010·Journal of Theoretical Biology·Taichiro KobayashiKouhei Akazawa

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