PMID: 3759572Aug 1, 1986Paper

Growth delay in a murine squamous cell tumor after local radiation and concurrent infusional 5-fluorouracil treatment

International Journal of Radiation Oncology, Biology, Physics
M J WeinbergA M Rauth

Abstract

In an effort to increase local control rates in a variety of human squamous cell carcinomas, infusional 5-Fluorouracil (5FU) has been combined with conventional fractionated radiation. The present work uses an experimental tumor system to examine the interactive effect of radiation and 5FU treatment. A transplantable murine tumor of squamous cell origin, SCC VII/SF, was grown in the legs of C3H mice. Leg diameter was measured and converted to tumor weight by an empirical calibration curve. Tumors of 0.3 g were treated by local irradiation with single or fractionated doses of 100 kVp X rays, alone, or in combination with a 7 day infusion of 5FU delivered by subcutaneously implanted mini-osmotic pumps. The tumor response was measured for single doses of 10-30 Gy and a fractionated dose of 5 Gy per day for 5 days. Studies done with single doses of radiation indicated delay and extent of tumor volume reduction, increased with dose. The effects of 5FU as a single agent were studied at infusion rates of 0.7, 1.3, or 2 mg/kg/hr for seven days. The LD50 for 5FU infusion was 1.3 mg/kg/hr. A single dose of 20 Gy or a fractionated dose of 5 Gy per day for 5 days was compared both in the presence and absence of 5FU at 0.7 mg/kg/hr. Results...Continue Reading

References

Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·K K FuK N Lam
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B J Cummings
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian

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Citations

Feb 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A K Speke, R P Hill
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A W BlackstockJ E Tepper
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K NewellI Tannock
Nov 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M J Weinberg, A M Rauth
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S Rockwell
Jul 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S L BrownR P Hill
Jan 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S V KozinY Tanaka

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