Growth Differentiation Factor 11 Promotes Abnormal Proliferation and Angiogenesis of Pulmonary Artery Endothelial Cells

Hypertension
Xiufeng YuDaling Zhu

Abstract

Disordered proliferation and angiogenesis of pulmonary artery endothelial cells is an important stage in the development of pulmonary arterial hypertension. Recent studies revealed that GDF11 (growth differentiation factor 11) induces endothelial cells proliferation and migration; however, whether GDF11 is directly involved in the pathogenesis of pulmonary arterial hypertension remains unknown. Here, we found that GDF11 was significantly upregulated and activated in 2 experimental pulmonary arterial hypertension models and cultured pulmonary artery endothelial cells. Genetic ablation of gdf11 in endothelial cells rescued pulmonary arterial hypertension features, as demonstrated by right ventricle hypertrophy, right ventricular systolic pressure, hemodynamics, cardiac function, and vascular remodeling. Moreover, we found that hypoxia significantly increased cell cycle progression, proliferation, migration, adhesion, and tube formation, which were significantly inhibited by GDF11 small interfering RNA. These events could be reproduced using cultured pulmonary artery endothelial cells and were dependent on Smad signaling. Moreover, hypoxia-induced GDF11 expression was regulated by the transcription factor zinc finger protein 740, ...Continue Reading

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M SchlaegerT N Sato
Apr 3, 2002·The EMBO Journal·Marie-José GoumansPeter ten Dijke
Feb 4, 2003·The Journal of Physiology·Katherine HowellPaul McLoughlin
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Jan 22, 2004·Circulation·Rohit BudhirajaPaul M Hassoun
Sep 24, 2004·The EMBO Journal·Franck LebrinPeter ten Dijke
Jan 25, 2005·Cardiovascular Research·Franck LebrinPeter Ten Dijke
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Sunil K HalderPran K Datta
Mar 7, 2007·Clinics in Chest Medicine·Rubin M TuderSonia Flores
May 29, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fares A MasriSerpil C Erzurum
Sep 16, 2009·Cloning and Stem Cells·Nicholas R F HannanErnst J Wolvetang
Dec 8, 2010·Disease Models & Mechanisms·Yoshinori ShimajiriMichael S German
Mar 19, 2014·Journal of Cellular and Molecular Medicine·Hitesh M PeshavariyaGregory J Dusting
Jun 12, 2014·Functional & Integrative Genomics·Mehanathan MuthamilarasanManoj Prasad
Jun 1, 2015·The Journal of Surgical Research·Günter FinkenzellerSandra Strassburg
Sep 7, 2016·Experimental Hematology·Ilaria CegliaAnna Rita Migliaccio
Mar 9, 2017·EMBO Molecular Medicine·David W HammersH Lee Sweeney
May 10, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Songhe LiangXiufeng Yu
Jun 24, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Huili ZhangJesse D Roberts

❮ Previous
Next ❯

Citations

May 14, 2020·Hypertension·UNKNOWN Editors
May 15, 2020·Science Translational Medicine·Lai-Ming YungPaul B Yu
Aug 28, 2020·Journal of Cellular and Molecular Medicine·Xingying QiWeiqing Liu
Jun 27, 2020·Journal of Cellular and Molecular Medicine·Chi ZhangHong Yu
Apr 4, 2019·Molecular Medicine Reports·Xiu-Jing ZhangZhe Hao
Oct 21, 2020·Experimental & Molecular Medicine·Joonho Suh, Yun-Sil Lee
Aug 21, 2020·The European Respiratory Journal·Christophe Guignabert, Marc Humbert
Feb 13, 2021·Cell Communication and Signaling : CCS·Lijie DongXiaorong Li
Jan 30, 2021·The European Respiratory Journal·Colin E EvansYou-Yang Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.