Growth dynamics and morphology of regenerating optic fibers in tectum are altered by injury conditions: an in vivo imaging study in goldfish.

Experimental Neurology
Amy J Dawson, Ronald L Meyer

Abstract

The dynamic behavior of axons in systems that normally regenerate may provide clues for promoting regeneration in humans. When the optic nerve is severed in adult goldfish, all axons regenerate back to the tectum to reestablish accurate connections. In adult mammals, regeneration can be induced in optic and other axons but typically few fibers regrow and only for short distances. These conditions were mimicked in the adult goldfish by surgically deflecting 10-20% of optic fibers from one tectum into the opposite tectum which was denervated of all other optic fibers by removing its corresponding eye. At 21-63 days, DiI was microinjected into retina to label a few fibers and the fibers were visualized in the living fish for up to 5-7 h. The dynamic behavior and morphology of these regenerating deflected fibers were analyzed and compared to those regenerating following optic nerve crush. At 3-4 weeks, deflected fibers were found to form more branches and to maintain many more branches than crushed fibers. Although both deflected and crushed fibers exhibited stochastic growth and retraction, deflected fibers spent more time growing but grew for less distance. At 2 months, both deflected and crushed fibers became much more stable. T...Continue Reading

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Citations

Feb 18, 2014·Survey of Ophthalmology·J Emanuel Ramos de CarvalhoReinier O Schlingemann
Sep 5, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cynthia M Solek, Marc Ekker
Mar 5, 2016·Experimental Neurology·Jeffrey P Rasmussen, Alvaro Sagasti

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