Growth dynamics of untreated glioblastomas in vivo

Neuro-oncology
Anne Line StensjøenErik Magnus Berntsen

Abstract

Glioblastomas are primary malignant brain tumors with a dismal prognosis. Knowledge of growth rates and underlying growth dynamics is useful for understanding basic tumor biology, developing realistic tumor models, and planning treatment logistics. By using repeated pretreatment contrast-enhanced T1-weighted MRI scans from 106 patients (aged 26-83 years), we studied the growth dynamics of untreated glioblastomas in vivo. Growth rates were calculated as specific growth rates and equivalent volume doubling times. The fit of different possible growth models was assessed using maximum likelihood estimations. There were large variations in growth rates between patients. The median specific growth rate of the tumors was 1.4% per day, and the equivalent volume doubling time was 49.6 days. Exploring 3 different tumor growth models showed similar statistical fit for a Gompertzian growth model and a linear radial growth model and worse fit for an exponential growth model. However, large tumors had significantly lower growth rates than smaller tumors, supporting the assumption that glioblastomas reach a plateau phase and thus exhibit Gompertzian growth. Based on the fast growth rate of glioblastoma shown in this study, it is evident that ...Continue Reading

References

Jun 1, 1987·Journal of Neurosurgery·P J KellyJ J Illig
Sep 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J WatlingJ G Cairncross
Jul 1, 1993·Annals of Biomedical Engineering·R L GallowayA L Failinger
Sep 1, 1964·British Journal of Cancer·A K LAIRD
May 13, 2005·IEEE Transactions on Bio-medical Engineering·Roberto Chignola, Roberto Israel Foroni
Mar 10, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·C PenningtonJ M Wardlaw
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Hana L P HarpoldKristin R Swanson
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent
Sep 22, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Harutomo HasegawaPaul Marks
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Aug 6, 2010·Journal of Neuro-oncology·Satoshi NakasuKazuhiko Nozaki
Nov 19, 2010·Current Oncology Reports·Eudocia C Quant, Patrick Y Wen
Feb 10, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anette StorsteinRené van Helvoirt
Mar 23, 2011·Journal of Neurosurgery·Nader SanaiMitchel S Berger
Feb 10, 2012·Journal of the Royal Society, Interface·Susan Christine MasseyKristin R Swanson
Sep 1, 2012·Case Reports in Neurological Medicine·Marcus D MazurDaniel W Fults
Jun 8, 2013·Physics in Medicine and Biology·Stefan BauerMauricio Reyes
Mar 19, 2014·Neuro-oncology·Ole SolheimAsgeir Store Jakola
Sep 6, 2014·Journal of Neurosurgery·Matthew M GrabowskiMichael A Vogelbaum

❮ Previous
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Citations

Feb 24, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Annika LattermannMechthild Krause
Jan 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Guillaume LouvelUNKNOWN Club de Neuro-Oncologie of Société Française deNeurochirurgie
Dec 25, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Luiz Victor Maia LoureiroSuzana Maria Fleury Malheiros
Jul 15, 2015·Neuro-oncology·Chaitra Badve, Andrew E Sloan
May 6, 2016·Frontiers in Neuroscience·Emrah Özcan, Tunahan Çakır
Oct 26, 2016·PloS One·Even Hovig FyllingenIngerid Reinertsen
Mar 17, 2017·World Neurosurgery·Anne Line StensjøenOle Solheim
May 9, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C BalañaS Villà
Jan 21, 2018·Scientific Reports·Morteza EsmaeiliIngerid Reinertsen
Jan 23, 2020·Journal of the Royal Society, Interface·Inmaculada C SorribesHarsh V Jain
Apr 8, 2020·The International Journal of Neuroscience·Nils SchröterBenjamin Berger
Jul 21, 2020·Journal of Neuropathology and Experimental Neurology·Vilde Elisabeth MikkelsenSverre Helge Torp
Sep 5, 2018·BMC Cancer·Vilde Elisabeth MikkelsenSverre Helge Torp
May 18, 2019·Neurosurgical Review·Davide Tiziano Di CarloPaolo Perrini
Dec 12, 2017·BioMed Research International·M-E OraiopoulouV Sakkalis
Mar 10, 2019·Journal of Neuro-oncology·Vanessa Montes SantosOlavo Feher
Jul 11, 2019·Molecular and Clinical Oncology·Magnus KvistenSverre H Torp
Nov 12, 2016·Journal of Neuro-oncology·Hans Kristian BøErik Magnus Berntsen
Oct 20, 2020·European Stroke Journal·Klaus Kaae AndersenTom Skyhøj Olsen
Oct 22, 2020·Acta neurochirurgica·Vilde Elisabeth MikkelsenSverre Helge Torp
Feb 11, 2021·PLoS Computational Biology·Juan Jiménez-SánchezVíctor M Pérez-García
Dec 29, 2020·Frontiers in Oncology·Kristie LiuFrank J Attenello
Jan 12, 2020·World Neurosurgery·Ke WangZhen Wu

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