PMID: 9650014Jul 3, 1998Paper

Growth effects of alpha-interferon but not of bombesin or angiotensin II are mediated by activation of STAT proteins

European Journal of Clinical Investigation
A PanskyC Beglinger

Abstract

The recently discovered Jak/STAT signal transduction pathway is associated with cytokine or growth factor receptors; whether members of the G protein-coupled receptor superfamily also activate this pathway is not yet clear. As a first member, the angiotensin (AT)1A receptor has been demonstrated to phosphorylate Jak and STAT proteins. Bombesin, a neurotransmitter and growth factor in many cells and tissues, activates its G protein-coupled receptor and in addition phosphorylates proteins that might be members of the Jak/STAT family. This study investigated whether bombesin- or angiotensin-mediated growth effects are associated with STAT protein activation. Functional receptors were characterized using ligand-binding studies, second-messenger activation and determination of ligand-mediated growth effects. STAT protein activation was analysed by electrophoretic mobility shift assay (EMSA) using labelled DNA response elements recognizing all known STAT proteins. Functional bombesin receptors mediating mitogenic effects were demonstrated on Swiss 3T3 fibroblasts, human melanoma cells (A375-6) and primary human lung fibroblasts; however, bombesin-related STAT protein activation was not observed by EMSA. Interferon-alpha typically act...Continue Reading

References

Jan 1, 1992·Tissue & Cell·M RothA P Perruchoud
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M EghbaliB Bhambi
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G GaudinoP M Comoglio
Jan 1, 1988·Annals of the New York Academy of Sciences·D N CarneyF Cuttitta
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T E HayesB H Cochran
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jan 1, 1995·Cancer Investigation·M L JaramilloJ C Bell
Oct 19, 1995·Nature·J N Ihle
Feb 1, 1995·Trends in Genetics : TIG·J N Ihle, I M Kerr
Sep 1, 1993·Circulation·D J DunckerR J Bache
Jun 1, 1993·Circulation Research·W SchorbK M Baker
Jan 1, 1996·European Journal of Clinical Investigation·M H Heim
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F BrombergJ E Darnell
Jan 1, 1997·European Journal of Clinical Investigation·A PanskyP Hildebrand

❮ Previous
Next ❯

Citations

Sep 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Jinbo Liu, Jeffrey A Kern
May 28, 2010·Journal of Cutaneous Pathology·Ryan J Sullivan, Michael B Atkins
Feb 1, 2000·Biochemical and Biophysical Research Communications·T SasaguriJ Ogata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.