Growth factor action in neural crest cell diversification

Journal of Anatomy
Maya Sieber-Blum, J M Zhang

Abstract

At the onset of their migration into the embryo, many neural crest cells are pluripotent in the sense that they have the capacity to generate progeny that consist of more than one cell type. More recently, we have found that there are pluripotent neural crest cell-derived cells even at sites of terminal differentiation. These findings support the notion that cues originating from the microenvironment, at least in part, direct neural crest cell type specification. Based on the rationale that growth factors that are known to support survival of neural crest cell derivatives may have additional functions in progenitor cell development, we have examined the action of pertinent growth factors. Trophic, mitogenic, antiproliferative and differentiation promoting activities were found. Stem cell factor (SCF) is trophic for pluripotent neural crest cells. Contrary to expectation, SCF plus a neurotrophin, rather than SCF alone is trophic for committed melanogenic cells. Basic fibroblast growth factor (bFGF) is mitogenic both for pluripotent cells and committed melanogenic cells. However, the cells become dependent on another factor for survival. Whereas any neurotrophin tested can rescue bFGF-activated pluripotent neural crest cells, the...Continue Reading

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Citations

Dec 11, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·O AmanoH C Slavkin
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Kubota, K Ito
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Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mitsunori Ota, Kazuo Ito
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Sep 6, 2007·Cells, Tissues, Organs·Nikolitsa Soulintzi, Nikolas Zagris

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