Mar 1, 1997

Growth factor-dependent phosphoinositide signalling

The International Journal of Biochemistry & Cell Biology
J J Hsuan, S H Tan

Abstract

A wide variety of messages, in the form of diffusible growth factors, hormones and cytokines, are carried throughout multicellular organisms to coordinate important physiological properties of target cells, such as proliferation, differentiation, migration, apoptosis and metabolism. Most messengers bind to cognate receptors on target cells, which initiate a characteristic cascade of reactions within the cell, ultimately leading to the desired response. The cellular response is defined by the combination of signalling components whose individual activity depends upon the number and type of surface receptors. Consequently the responses of different cell types to one or more stimuli can be quite disparate. A molecular understanding of the signalling pathways employed by each type of receptor therefore underlies the ability to rationalize many cellular functions and to correct disfunctions. As a well studied example of the primary signalling events that take place on the cytoplasmic leaflet of the plasma membrane following receptor activation, we will discuss how the widely expressed receptor for epidermal growth factor (EGF) causes the phosphorylation and hydrolysis of a signalling precursor, the membrane lipid phosphatidylinosito...Continue Reading

  • References139
  • Citations12

References

  • References139
  • Citations12

Mentioned in this Paper

Phosphatidylinositols
Phosphatidylinositol 3-Kinases
Type C Phospholipases
Phospholipid scramblase
Serum Proteins
Growth Substances
Epidermal Growth Factor Receptor
1-Phosphatidylinositol 4-Kinase
Phosphotyrosine
SH3 Domain

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