Growth factor-dependent proliferation and invasion of muscle satellite cells require the cell-associated fibrinolytic system

Biological Chemistry
G FibbiM Del Rosso

Abstract

The process of muscle regeneration in normal and dystrophic muscle depends on locally produced cytokines and growth factors and requires the activity of the urokinase plasminogen activator/urokinase plasminogen activator receptor/plasminogen activator inhibitor-1 system. In this study we tested the effect of basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF) and transforming growth factor-beta (TGFbeta) on the fibrinolytic pattern of normal and dystrophic satellite cells, their mitogenic and motogenic activities and the dependence of such activities on the cell-associated fibrinolytic system. We have observed that the urokinase plasminogen activator (u-PA) receptor is weakly upregulated by bFGF in normal satellite cells, while it is strongly up-regulated by TGFbeta, mainly in dystrophic myoblasts. bFGF up-regulated u-PA in both normal and dystrophic myoblasts grown in primary culture, while a striking down-regulation was observed with TGFbeta. TGFbeta was the only growth factor able to exceptionally up-regulate plasminogen activator inhibitor-1 (PAI-1), mainly in dystrophic satellite cells. HGF did not show any activity on the fibrinolytic system. Proliferation and invasion into Matrigel matrices of normal an...Continue Reading

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Citations

Mar 8, 2014·European Journal of Applied Physiology·Ryan M FrancisJeffrey T Lemmer
Oct 23, 2008·The Journal of Biological Chemistry·Jianming LiuStephen J Kaufman
Jun 24, 2014·Acta Biomaterialia·Young Min JuSang Jin Lee
Oct 11, 2016·Journal of Tissue Engineering and Regenerative Medicine·Mei-Chi ChangJiiang-Huei Jeng
Feb 18, 2005·American Journal of Physiology. Cell Physiology·Timothy J KohThomas H Sisson
Oct 1, 2020·International Journal of Molecular Sciences·Fasih Ahmad Rahman, Matthew Paul Krause

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