PMID: 7525114Jul 15, 1994Paper

Growth factor effects on the proliferation of different retinal glial cells in vitro

Brain Research. Developmental Brain Research
J Scherer, J Schnitzer

Abstract

Vascularized mammalian retinae contain two distinct neuroglial cells types, radially oriented Müller cells and astrocytes, which are located in the nerve fiber layer. These cell types derive from different precursor cells and proliferate during ontogenesis at distinct schedules. The aim of the present study was to disclose whether growth factors, which are known to interfere with the development of neuroglial cells in the central nervous system, like basic and acidic fibroblast growth factor (aFGF and bFGF), epidermal growth factor (EGF) and platelet-derived growth factor, have similar or distinct effects on the proliferative capacity of retinal astrocytes and Müller cells. These questions were tested by applying growth factors to cultured astrocytes and Müller cells from early postnatal rabbit retina. Proliferating cells were identified by double labeling experiments combining cell type specific markers with bromodeoxyuridine immunocytochemistry and [3H]thymidine incorporation experiments, respectively. In addition, we used the anatomical advantage of the rabbit retina. Its peripheral part is astroglial cell-free. Cultures prepared from this part of the retina (P-cultures) contain Müller cells, microglial cells and neurons, wh...Continue Reading

References

Sep 1, 1975·Archives of Ophthalmology·M O TsoI W McLean
Sep 1, 1991·The Journal of Comparative Neurology·A ReichenbachA Henke
Dec 22, 1990·The Journal of Comparative Neurology·J Schnitzer, J Scherer
Jan 1, 1990·Progress in Growth Factor Research·J W McAvoy, C G Chamberlain
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O BöglerM Noble
Feb 22, 1990·The Journal of Comparative Neurology·J Schnitzer
Oct 8, 1985·The Journal of Comparative Neurology·J Schnitzer
Jul 1, 1989·The Journal of Cell Biology·D B Rifkin, D Moscatelli
Feb 1, 1989·Journal of Cellular Biochemistry·D CaruelleD Barritault
Sep 15, 1989·The Journal of Comparative Neurology·K Ashwell
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F BesnardG Labourdette
Jan 1, 1989·Acta Physiologica Scandinavica. Supplementum·E A Newman, C J Karwoski
Aug 1, 1988·Journal of Neurocytology·M B GraeberG W Kreutzberg
Apr 28, 1988·Nature·T Watanabe, M C Raff
Jul 1, 1988·Archives of Ophthalmology·E de JuanL Hjelmeland
Jul 31, 1987·Biochemical and Biophysical Research Communications·F MascarelliY Courtois
Aug 1, 1985·Brain Research·P A Eccleston, D H Silberberg
Feb 1, 1980·American Journal of Ophthalmology·J L FedermanS M Felton

❮ Previous
Next ❯

Citations

Nov 21, 1995·Brain Research. Developmental Brain Research·J SchererJ Schnitzer
May 26, 1999·The British Journal of Ophthalmology·M XiaoM Boulton
Dec 22, 2004·Progress in Retinal and Eye Research·Andy J Fischer
Oct 1, 1995·Glia·K R HuxlinB Dreher
Jul 1, 1997·Journal of Neurophysiology·A Bordey, H Sontheimer
Jun 9, 2021·Progress in Retinal and Eye Research·Andreas BringmannPeter Wiedemann
Aug 8, 2009·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.