PMID: 8601887Mar 1, 1996Paper

Growth factor production after polytetrafluoroethylene and vein arterial grafting: an experimental study

Journal of Vascular Surgery
A V SterpettiS Stipa

Abstract

Occlusion caused by myointimal hyperplasia appears to be the main reason of late failure of polytetrafluoroethylene (PTFE) arterial bypass grafts. Evidence exists that growth factors are involved in the genesis of myointimal hyperplasia. The aim of this study was to assess the release of platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) by PTFE arterial grafts. In 15 inbred Lewis rats a 1 cm long segment of PTFE was interposed at the level of the abdominal aorta. In a control of another 15 Lewis rats in a vein graft was implanted at the level of the abdominal aorta. Animals were killed four weeks after implantation and the tissue was studied in organ culture for release of PDGF AA, PDGF BB, and bFGF. PTFE grafts released a greater quantity of PDGF AA than did control vein grafts (28 +/- 4 ng/cm2/72 hr vs 7 +/- 2 ng/cm2/72 hr). Similarly, PTFE grafts released a greater quantity of bFGF than did arterial vein grafts (308 +/- 22 ng/cm(2)/72hr vs 204 +/- 20 ng/cm2/72 hr). We conclude that PTFE arterial grafts released a high quantity of growth factor, which could explain, in part, the occurrence of distal anastomotic myointimal hyperplasia.

References

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Citations

Dec 17, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B RandoneA V Sterpetti
Aug 11, 2007·Biomaterials·Peter ZillaPaul Human
Oct 27, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M H WuL R Sauvage
Nov 30, 2005·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P D DevereuxT McGloughlin
Oct 26, 2016·Journal of Vascular Surgery·Antonio V SterpettiMarco Ventura

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