PMID: 9437800Jan 23, 1998Paper

Growth factor responses and protooncogene expression of murine mesothelial cell lines derived from asbestos-induced mesotheliomas

Toxicologic Pathology
L A GoodglickAgnes B Kane

Abstract

Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern in vivo and were tumorigenic when reinjected into syngeneic mice. Similar to human mesothelial cells, growth of the murine cell lines was stimulated by epidermal growth factor. Reactive mesothelial cells and mesotheliomas expressed the receptor for this growth factor. Crocidolite asbestos fibers have been reported to induce sustained expression of the c-fos and c-jun protooncogenes in rat pleural mesothelial cells in vitro (Heintz et al, Proc. Natl. Acad. Sci. USA 90: 3299-303, 1993). Human malignant mesotheliomas have been shown to express c-fos in situ (Ramael et al, Histol. Histopathol. 10: 639-643, 1995). Two of the cell lines derived from highly invasive murine mesotheliomas overexpressed c-fos and c-jun. This murine model recapitulates the histopathology, growth factor responses, and protooncogene expression of human malignant mesotheliomas.

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Citations

Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nathan R MiselisAgnes B Kane
Jul 5, 2017·Frontiers in Pharmacology·Laura MasuelliRoberto Bei
Sep 17, 2005·Cancer Research·Deborah A AltomareJoseph R Testa
Apr 1, 2008·Molecular Cancer Therapeutics·Nathan R MiselisAgnes B Kane
Sep 24, 2019·Seminars in Cancer Biology·Trista K Hinz, Lynn E Heasley
Aug 2, 2005·Lancet·Bruce W S RobinsonRichard A Lake
Jan 6, 2017·The American Journal of Pathology·Joyce K ThompsonArti Shukla

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