Growth factor therapy and lymph node graft for lymphedema

The Journal of Surgical Research
Tomi TervalaAnne M Saarikko

Abstract

Lymphedema still remains an unsolved problem. Secondary lymphedema often develops after cancer operations or radiation therapy, especially in breast cancer patients. Using a mouse model, we show here that the lymphatic network can be regenerated using lymphatic vascular growth factor therapy in combination with lymph node transfer. We have compared the therapeutic effects of different vascular endothelial growth factors (VEGF-C, VEGF-D, VEGF-C156S, and VEGF-A), in combination with lymph node transfer in mouse axilla. The lymphangiogenic effects of the growth factor therapy were examined at 3 mo postoperatively. VEGF therapy with VEGF-C and VEGF-D induced growth of new lymphatic vessels in the defect area, and VEGF-C also improved lymphatic vessel function compared with that of controls. VEGF-C156S induced moderate lymphangiogenesis, but the effect remained statistically nonsignificant. Prolymphangiogenic growth factors (VEGF-C, -D, and -C156S) also improved lymph node survival as compared with those of the VEGF-A and control group. VEGF-C, which activates both vascular endothelial growth factor receptor 2 and vascular endothelial growth factor receptor 3, gave the best therapeutic effect in this experimental lymphedema model. T...Continue Reading

References

Jun 1, 1979·Plastic and Reconstructive Surgery·B F ShesolR W Hamilton
Oct 1, 1991·The Journal of Cell Biology·R E MebiusG Kraal
Jul 1, 1982·Annals of Surgery·J A RabsonJ W Futrell
May 30, 1997·Science·M JeltschK Alitalo
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
May 18, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·M A SchnellJ M Wilson
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·M J KarkkainenK Alitalo
Sep 18, 2002·The Journal of Experimental Medicine·Anne SaaristoKari Alitalo
Oct 25, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SzubaStanley G Rockson
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jun 15, 2004·Journal of Dermatological Science·Satoshi Hirakawa, Michael Detmar
Sep 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne SaaristoKari Alitalo
Dec 14, 2004·Genesis : the Journal of Genetics and Development·Kristina VinterstenAndras Nagy
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Jan 11, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeremy GoldmanMelody A Swartz
May 31, 2007·The Journal of Experimental Medicine·Maria WirzeniusKari Alitalo
May 16, 2009·Circulation Research·Andrey AnisimovKari Alitalo
Feb 2, 2011·Circulation·Markku LähteenvuoAnne Saaristo
Nov 9, 2011·Nature Medicine·Kari Alitalo
Aug 11, 2012·Plastic and Reconstructive Surgery·Tiina P ViitanenAnne M Saaristo
Sep 28, 2012·Annals of Surgery·Krista M HonkonenAnne M Saaristo
Oct 13, 2012·Frontiers in Immunology·Eric F TewaltVictor H Engelhard
Jan 29, 2014·Plastic and Reconstructive Surgery·Seth Z AschenBabak J Mehrara
May 1, 2013·Plastic and Reconstructive Surgery. Global Open·Tiina P ViitanenAnne M Saaristo

❮ Previous
Next ❯

Citations

Feb 13, 2016·Annual Review of Biomedical Engineering·Timothy P PaderaLance L Munn
Jan 28, 2017·Lymphatic Research and Biology·Rebecca Hadrian, Daniel Palmes
Feb 28, 2018·Frontiers in Bioengineering and Biotechnology·Khushbu RauniyarMichael Jeltsch
Aug 17, 2018·Journal of Surgical Oncology·Anna Rose Johnson, Dhruv Singhal
Jan 13, 2018·Nature Reviews. Rheumatology·Echoe M BoutaEdward M Schwarz
Jun 1, 2018·Contrast Media & Molecular Imaging·Linpeng YaoFeng Chen
Jul 7, 2019·The International Journal of Biochemistry & Cell Biology·Florent Morfoisse, Agnès Noel
Feb 1, 2021·Journal of Reconstructive Microsurgery·Andreas SpörleinChristoph Hirche
Jun 16, 2021·Advances in Wound Care·Jerry F HsuAlex K Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.