Growth factor therapy and neuronal nitric oxide synthase

International Journal of Impotence Research
C S Lin, Tom F Lue

Abstract

Trauma to the cavernous nerve is a known cause of erectile dysfunction, with lengthy and often incomplete recovery. Using rat models, we have previously shown that injury to the cavernous nerves or ligation of pudendal arteries causes a significant decrease of neuronal nitric oxide synthase (nNOS) in the dorsal nerve of the penis and intracavernosal tissue as well as loss of erectile response to neurostimulation. Intracavernous injection of vascular endothelial growth factor or brain-derived neurotrophic factor facilitates the recovery of nNOS and erectile function. Studies are underway to elucidate the molecular mechanism of cavernous nerve regeneration and the potential of using growth factors to enhance the recovery of erectile function in patients after radical pelvic surgery. International Journal of Impotence Research (2004) 16, S38-S39. doi:10.1038/sj.ijir.3901214

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Citations

Dec 19, 2007·Asian Journal of Andrology·Donghua XieCraig F Donatucci
Oct 11, 2014·Pharmacogenomics·Riccardo Lacchini, Jose E Tanus-Santos
Sep 10, 2014·Expert Opinion on Drug Discovery·Haroldo A Toque, Robert William Caldwell
Dec 8, 2011·The Journal of Sexual Medicine·Maarten AlbersenJeffrey L Spees
Feb 12, 2009·The Journal of Sexual Medicine·Hongxiu NingChing-Shwun Lin
Aug 9, 2011·The Journal of Sexual Medicine·Ruibao ChenZhangqun Ye
Jul 14, 2007·The Journal of Sexual Medicine·Donghua XieBrian H Annex
Dec 15, 2012·The Journal of Sexual Medicine·Christopher W BondCarol A Podlasek
Dec 21, 2012·The Journal of Sexual Medicine·Xuefeng QiuChing-Shwun Lin
Sep 5, 2006·European Urology·Muammer KendirciTrinity J Bivalacqua
Aug 19, 2017·International Journal of Molecular Sciences·Jeffrey D Campbell, Arthur L Burnett
Jul 25, 2012·Nature Reviews. Urology·Lukman HakimMaarten Albersen

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