Growth factor treatment to overcome Alzheimer's dysfunctional signaling

Cellular Signalling
Marc-Antoine LauzonNathalie Faucheux

Abstract

The number of people suffering from Alzheimer's disease (AD) will increase as the world population ages, creating a huge socio-economic burden. The three pathophysiological hallmarks of AD are the cholinergic system dysfunction, the β-amyloid peptide deposition and the Tau protein hyperphosphorylation. Current treatments have only transient effects and each tends to concentrate on a single pathophysiological aspect of AD. This review first provides an overall view of AD in terms of its pathophysiological symptoms and signaling dysfunction. We then examine the therapeutic potential of growth factors (GFs) by showing how they can overcome the dysfunctional cell signaling that occurs in AD. Finally, we discuss new alternatives to GFs that help overcome the problem of brain uptake, such as small peptides, with evidence from some of our unpublished data on human neuronal cell line.

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Citations

Dec 3, 2016·Regenerative Medicine·James Koudy Williams, Karl-Erik Andersson
Oct 5, 2017·International Journal of Molecular Sciences·Chiara Bianca Maria PlataniaClaudio Bucolo
Dec 1, 2017·Acta Biochimica Et Biophysica Sinica·Risa Kashima, Akiko Hata
Jan 7, 2019·Molecular Neurobiology·Kinga CzubowiczRobert P Strosznajder
Dec 15, 2020·Neurochemistry International·Michael VoronkovJeffry B Stock
Jul 3, 2021·International Journal of Molecular Sciences·Suzanne GasconNathalie Faucheux

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