Growth Factors and COX2 Expression in Canine Perivascular Wall Tumors

Veterinary Pathology
G AvalloneP Roccabianca

Abstract

Canine perivascular wall tumors (PWTs) are a group of subcutaneous soft tissue sarcomas developing from vascular mural cells. Mural cells are involved in angiogenesis through a complex crosstalk with endothelial cells mediated by several growth factors and their receptors. The evaluation of their expression may have relevance since they may represent a therapeutic target in the control of canine PWTs. The expression of vascular endothelial growth factor (VEGF) and receptors VEGFR-I/II, basic fibroblast growth factor (bFGF) and receptor Flg, platelet-derived growth factor B (PDGFB) and receptor PDGFRβ, transforming growth factor β1 (TGFβ1) and receptors TGFβR-I/II, and cyclooxygenase 2 (COX2) was evaluated on frozen sections of 40 PWTs by immunohistochemistry and semiquantitatively scored to identify their potential role in PWT development. Statistical analysis was performed to analyze possible correlations between Ki67 labeling index and the expression of each molecule. Proteins of the VEGF-, PDGFB-, and bFGF-mediated pathways were highly expressed in 27 (67.5%), 30 (75%), and 19 (47.5%) of 40 PWTs, respectively. Proteins of the TGFβ1- and COX2-mediated pathways were highly expressed in 4 (10%) and 14 (35%) of 40 cases. Statist...Continue Reading

References

Jun 16, 2000·Endocrine·L P ReynoldsD A Redmer
Apr 8, 2003·Journal of Pediatric Hematology/oncology·David S DickensTimothy P Cripe
Jun 17, 2003·Cell Structure and Function·Mitsuru SatoHaruki Senoo
Jun 29, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen K K ShearesNicholas W Morrell
May 16, 2007·Cancer Immunology, Immunotherapy : CII·Debra KamstockSteven Dow
Oct 3, 2007·The Journal of Clinical Investigation·Lars Johan NissenYihai Cao
Oct 1, 2008·Journal of Veterinary Internal Medicine·K A HahnO Hermine
Feb 11, 2009·Journal of Comparative Pathology·P Dias PereiraC Lopes
Nov 26, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Colin J McCarthyPatrick J Broe
Jan 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Genilson Fernandes de QueirozJulia Maria Matera
Aug 3, 2010·The Veterinary Journal·Felisbina L QueirogaCarlos S Lopes
Dec 9, 2010·Veterinary Pathology·M M DennisB E Powers
May 17, 2011·Veterinary and Comparative Oncology·Z BelshawJ M Dobson
Aug 16, 2011·Developmental Cell·Annika ArmulikChrister Betsholtz
Nov 15, 2011·Journal of Comparative Pathology·Justina PradaIsabel Pires
Mar 1, 2012·Veterinary and Comparative Oncology·G Fernandes de QueirozJ Maria Matera
Aug 7, 2012·Veterinary Pathology·C PalmieriL Della Salda

❮ Previous
Next ❯

Citations

Nov 30, 2019·Veterinary and Comparative Oncology·Giancarlo AvallonePaola Roccabianca
Oct 5, 2016·Veterinary Pathology·G AvalloneG Sarli
Jun 30, 2018·Case Reports in Veterinary Medicine·Terry M JacobsMatti Kiupel
Feb 27, 2021·Topics in Companion Animal Medicine·Lucas Cavalli KluthcovskyJair Rodini Engracia Filho

❮ Previous
Next ❯

Software Mentioned

Image Pro Plus

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.