Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

Molecular Medicine Today
D M DanilenkoG F Pierce

Abstract

Hair growth disorders, particularly those that lead to hair loss (alopecia), are common and frequently cause significant mental anguish in affected individuals. The mechanisms underlying the majority of these disorders are unknown. However, insights into the specific molecular mechanisms of hair follicle development and cycling have recently been made using animal models, particularly mice that over- or underexpress a specific gene for a growth factor or cytokine. Other animal models have demonstrated that certain growth factors and cytokines can prevent much of the alopecia caused by cancer chemotherapeutic agents. These animal models have confirmed the importance of growth factors and cytokines in hair follicle development and cycling, and have formed the foundation for potential clinical therapy of hair growth disorders, particularly alopecia. Nevertheless, important questions concerning their efficacy, safety and delivery will need to be answered before successful clinical therapy of any hair growth disorder becomes a reality.

References

Jan 1, 1992·The Journal of Investigative Dermatology·D L du CrosG P Moore
Feb 1, 1992·Trends in Genetics : TIG·M H Hardy
Jul 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J J JimenezA A Yunis
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J J WysolmerskiW M Philbrick
Jan 1, 1993·Reproduction, Fertility, and Development·B A Panaretto
Aug 11, 1995·Science·S MitragotriR Langer
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K SellheyerD R Roop
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·W H SunN S Yang
May 1, 1995·The Journal of Investigative Dermatology·C K GoldmanG Y Gillespie
Jul 1, 1994·Journal of Dermatological Science·M P PhilpottT Kealey
Jul 1, 1994·Journal of Dermatological Science·S ShimaokaH Ogawa
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·M F HolickK S Persons
Sep 1, 1994·The Journal of Investigative Dermatology·T JindoH Ogawa
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A L BalsariM I Colnaghi
Jan 1, 1996·The Journal of Investigative Dermatology·S LachgarJ Plouët
Feb 1, 1996·The Journal of Investigative Dermatology·J P Sundberg, L E King

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Citations

Jul 24, 2008·Archives of Dermatological Research·Justyna Niderla-BielinskaStanislaw Moskalewski
Sep 15, 2006·Pharmaceutical Research·Jie WangJessie L-S Au
Sep 3, 2002·Survey of Ophthalmology·Murray A Johnstone, Daniel M Albert
Aug 12, 1999·The New England Journal of Medicine·R Paus, G Cotsarelis
Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yukio YonedaRyotaro Yoshida
Sep 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Masashi OkadaRyotaro Yoshida
Jan 7, 2014·Biological & Pharmaceutical Bulletin·Jae-Suk ChoiMi-Ryung Kim
May 7, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jingjie LiChangkeun Sung
Dec 8, 2009·Journal of Dermatological Science·Chong Hyun WonKyu Han Kim
Jan 16, 2010·Forensic Science International : Synergy·Joey Gareri, Gideon Koren
Jan 20, 2009·Cancer·Olga PozdnyakovaStephen Lyle
Feb 12, 2011·American Journal of Physical Anthropology·L J WilliamsF J Longstaffe
Sep 23, 2006·Mechanisms of Development·Tokuro Iwabuchi, Paul F Goetinck
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan ZhangYu-Qing Zhao
Dec 14, 1999·The Journal of Investigative Dermatology·N W RufautR J Wilkins
Mar 12, 2002·The Journal of Investigative Dermatology·M IguchiH Tagami
Aug 19, 2000·Endocrine Reviews·R AzzizM E Sawaya
Aug 19, 2000·Endocrine Reviews·D Deplewski, R L Rosenfield
Feb 6, 2018·Laboratory animal research·Jong-Hwan KimByeong-Cheol Kang
Nov 13, 2001·American Journal of Clinical Dermatology·L FalsettiL Legrenzi
Dec 22, 2017·Anais Da Academia Brasileira De Ciências·Chun HouWeijin Hong

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