Growth factors and IL-17 in hereditary angioedema

Clinical and Experimental Medicine
M SalemiE Cillari

Abstract

Hereditary angioedema (HAE) is a rare autosomal dominant disorder, due to C1-inhibitor deficiency, which causes episodic swellings of subcutaneous tissues, bowel walls and upper airways which are disabling and potentially life-threatening. We evaluated n = 17 patients with confirmed HAE diagnosis in basal and crisis state and n = 19 healthy subjects. The samples were tested for IL-17, FGFb, G-CSF and GM-CSF, using Bio-plex kit. Data analysis was performed via nonparametric Spearman's correlations and two sets of linear mixed models. When comparing HAE subjects during basal and crisis states, we found out significantly (i.e., p value <0.05) higher values in crisis states rather than in basal states for the three growth factors and cytokine IL-17. When comparing healthy subjects versus HAE patients at basal state, we found out significantly higher values in HAE subjects only for GM-CSF, FGFb and IL-17, but not for G-CSF. In HAE patients, there is a connection between IL-17 and growth factors. The low-grade inflammation in absence of attacks is demonstrated by constant higher amount of IL-17, FGFb and GM-CSF with respect to healthy patients. This could indicate that in this disease there is a level of activation that maintains the...Continue Reading

References

Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C FelicianiD N Sauder
Sep 12, 1998·Lancet·J NussbergerA Agostoni
Feb 1, 1996·Cancer Biotherapy & Radiopharmaceuticals·A Jakubowski, J Gabrilove
Feb 14, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Atsuhiro OgawaYoshihide Fujiyama
Aug 6, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Susanne BraunSabine Werner
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael PlattenLawrence Steinman
Oct 3, 2009·Nature Reviews. Rheumatology·Ann L CornishIan P Wicks
Nov 6, 2009·Blood·Martin PelletierMarco A Cassatella
Feb 9, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Dorottya CsukaLilian Varga
Aug 7, 2013·BMC Gastroenterology·Isao OhsawaYasuhiko Tomino
Jan 9, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Francesco ArcoleoEnrico Cillari
Feb 14, 2014·The Journal of Allergy and Clinical Immunology·Erika KajdácsiLászló Cervenak

❮ Previous
Next ❯

Citations

Jan 7, 2016·British Journal of Haematology·Takashi WatanabeShinsuke Iida
Apr 27, 2016·Clinical Reviews in Allergy & Immunology·Anastasios E Germenis, Matthaios Speletas
May 5, 2016·Clinical Reviews in Allergy & Immunology·Henriette FarkasLilian Varga
Apr 7, 2018·Clinical and Experimental Medicine·Francesco ArcoleoEnrico Cillari
Feb 10, 2021·Clinical Reviews in Allergy & Immunology·Grzegorz PorebskiAvner Reshef
May 30, 2021·Clinical Reviews in Allergy & Immunology·Anne Lise FerraraStefania Loffredo

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
D MoldovanMarco Cicardi
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
David A WilsonWilliam E Pullman
© 2021 Meta ULC. All rights reserved