PMID: 2498163Mar 1, 1989Paper

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction

Genes & Development
D P BartelM E Greenberg

Abstract

A set of early response genes has been identified whose transcription in fibroblasts is rapidly induced in response to growth factors. Prototype members of this group, c-fos and c-jun, encode products that form a heterodimer and have been implicated in the regulation of gene expression and cell growth. It is thought that other early response genes also encode critical mediators of the cell's response to external stimuli. We have used PC12 pheochromocytoma cells as a model system to test the hypothesis that different extracellular signals induce distinct patterns of expression of early response genes. Our results indicate that membrane depolarization, induced either by potassium chloride or by the neurotransmitter analog nicotine, activates a program of gene expression distinct from that activated by nerve growth factor or epidermal growth factor. Notably, c-fos and c-jun activation can be dissociated; whereas c-jun is coinduced with c-fos and jun-B after growth factor stimulation, membrane depolarization activates c-fos and jun-B without stimulating c-jun. Fos may therefore form transcription complexes with alternative cofactors under different stimulation conditions. nur/77 and zif/268, which encode putative transcription fact...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Aug 7, 1986·Nature·J I Morgan, T Curran
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Curran, J I Morgan
Aug 18, 1988·Nature·W W LamphI M Verma
Dec 1, 1988·Genes & Development·F J RauscherT Curran
Dec 15, 1988·Nature·T Kouzarides, E Ziff
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W KruijerI M Verma
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y MakiP K Vogt
Dec 5, 1986·Cell·R Prywes, R G Roeder
May 20, 1988·Science·F J RauscherB R Franza
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L J JosephV P Sukhatme
Nov 4, 1988·Cell·T Curran, B R Franza
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D W SaffenJ M Baraban
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T G HazelL F Lau
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Ryder, D Nathans
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K RyderD Nathans
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans

❮ Previous
Next ❯

Citations

Jun 1, 1994·Annals of Neurology·A HandforthD M Treiman
Jan 1, 1993·Developmental Genetics·K H SchlingensiepenW Brysch
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M M HurleyM Kessler
Aug 1, 1993·Journal of Neuroscience Research·H Z ShengP G Nelson
Mar 1, 1995·Journal of Neuroscience Research·L A Riley, J J Bernstein
Sep 1, 1990·Cellular and Molecular Neurobiology·D A Carter, D Murphy
Jun 1, 1994·Cellular and Molecular Neurobiology·E L Ochoa
May 1, 1996·Behavior Genetics·J M KornhauserJ S Takahashi
Oct 20, 1999·Journal of Molecular Neuroscience : MN·S AronovI Ginzburg
May 20, 1998·Journal of Molecular Neuroscience : MN·A S HazellA M Hakim
Jan 1, 1990·Molecular Neurobiology·E L OchoaM G McNamee
Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Dec 31, 1993·Brain Research·Z C PengM Bentivoglio
Dec 1, 1992·The International Journal of Biochemistry·J Vanden BroeckP Callaerts
Nov 1, 1993·Journal of the Neurological Sciences·D Leifer, N W Kowall
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·L M ManessJ E Zadina
Feb 16, 1995·Brain Research. Developmental Brain Research·K L LankfordJ D Kocsis
Nov 21, 1995·Brain Research. Developmental Brain Research·D von AgostonD E Brenneman
Oct 1, 1991·Trends in Pharmacological Sciences·T M Esterle, E Sanders-Bush
Jun 30, 1994·Biochimica Et Biophysica Acta·J Szeberényi, P Erhardt
Nov 1, 1989·Brain Research. Molecular Brain Research·S VidalM J Weber
Sep 1, 1991·Brain Research. Molecular Brain Research·M SimonatoJ O McNamara
Jun 1, 1992·Brain Research. Molecular Brain Research·K J MackP J Farnham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.