PMID: 8580997Jan 1, 1995Paper

Growth factors as mediators of androgen action during the development of the male urogenital tract

World Journal of Urology
G R CunhaA A Donjacour

Abstract

Studies on the developing prostate and SV suggest that androgens act via mesenchymal AR to elicit synthesis and secretion of various autocrine and paracrine factors that regulate epithelial and stromal growth and differentiation. Clearly, the global regulation of epithelial growth and ductal branching morphogenesis is a complex multifactorial process involving the interplay of many diffusible factors (both positive and negative regulators), extracellular matrix molecules, cell-surface receptors for growth factors, receptors for extracellular matrix molecules, and matrix-degrading enzymes. Future progress will certainly be dependent upon the utilization of appropriate, biologically relevant models to examine the respective roles of various growth factors in the growth and development of androgen target organs.

Citations

Apr 13, 2010·In Vitro Cellular & Developmental Biology. Animal·Xiaojuan SunRuoxiang Wang
Dec 18, 2002·Cytokine & Growth Factor Reviews·Emma M A Ball, Gail P Risbridger
Sep 24, 2011·Differentiation; Research in Biological Diversity·Barry G Timms, Luke E Hofkamp
Mar 14, 2009·Differentiation; Research in Biological Diversity·Xiaohong LiNeil A Bhowmick
May 9, 2008·Differentiation; Research in Biological Diversity·Barry G Timms
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Oct 28, 2008·Developmental Biology·Kenichiro IshiiYoshiki Sugimura
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Mar 22, 2002·Biochemical and Biophysical Research Communications·Hong ZhaoRajvir Dahiya

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