PMID: 8442425Jan 1, 1993Paper

Growth factors during proliferation of the middle ear mucosa

Acta Oto-laryngologica
A F Ryan, A Baird

Abstract

The presence of growth factors during otitis media with effusion (OME), induced by antigenic stimulation of the middle ear, was explored in guinea pigs. There was a significant increase in heparin-binding proliferative activity detected in mucosal tissue. This heparin-binding activity was identified as basic fibroblast growth factor (FGF) using several criteria. First, the majority of this activity was eluted from heparin-Sepharose gels with 1.3-1.8 M NaCl, consistent with basic FGF. Second, these fractions are potent stimulators of endothelial cell proliferation, characteristic of basic FGF. Third, the fractions contain basic FGF-like immunoreactivity based on radioimmunoassay. Finally, Western blotting of tissue extracts reveals the presence of an 18 kDa protein that is indistinguishable from basic FGF. We conclude that basic FGF plays a major role in the proliferation of the middle ear mucosa during OME.

References

Mar 1, 1979·Acta Oto-laryngologica·W KuijpersE C Willart
Mar 1, 1977·The Annals of Otology, Rhinology, and Laryngology·M Tos, K Bak-Pedersen
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·D J Lim
Mar 1, 1991·The Laryngoscope·A CatanzaroS I Wasserman
Mar 1, 1990·Acta Oto-laryngologica·T D KrekorianJ P Harris
Nov 1, 1988·Archives of Otolaryngology--head & Neck Surgery·T F DeMariaD J Lim
Jun 1, 1988·Clinical Otolaryngology and Allied Sciences·J H Dempster, I R Swan
May 1, 1986·The Annals of Otology, Rhinology, and Laryngology·A F RyanJ P Harris
Mar 1, 1987·The Journal of Cell Biology·D SchubertA Baird
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F EschR Guillemin
Dec 1, 1971·The Annals of Otology, Rhinology, and Laryngology·D J Lim, H Birck
Sep 1, 1980·The Annals of Otology, Rhinology, and Laryngology·S H LowellG S Giebink

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Citations

Dec 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M Kato, R K Jackler
Oct 4, 2012·Tissue Engineering. Part B, Reviews·Bing Mei TehMarcus D Atlas
Nov 1, 1996·Acta Oto-laryngologica·T F DemariaD G Danahey
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rahul MittalXue Zhong Liu
Aug 2, 2002·The Laryngoscope·Benedikt SedlmaierSergije Jovanovic
May 19, 2001·The Laryngoscope·S D PalaciosA F Ryan
Aug 1, 2002·The Laryngoscope·Sean D PalaciosAllen F Ryan
Feb 24, 2001·The Laryngoscope·A F Ryan, T Bennett
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Diego ZanettiLuca O Redaelli de Zinis
Dec 19, 2013·The Laryngoscope·Nyall R London, Richard K Gurgel
Jul 13, 1999·The Laryngoscope·S M LamJ M Ahn
Dec 16, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P S NassifP J Nicklaus

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