Growth factors, extracellular matrix components and cell adhesion molecules Warthin's tumor

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Y NakamuraT Nakashima

Abstract

We studied expressions of various growth factors, their receptors, cell adhesion molecules and extracellular matrix components in Warthin's tumor of the salivary gland with immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Various growth factors and their receptors, such as transforming growth factor-alpha (TGF-alpha), heparin-binding epidermal growth factor-like growth factor (HB-EGF), TGF-beta2, TG-beta3, insulin-like growth factor (IGF)-I and -II, vascular endothelial growth factor (VEGF), EGF receptor (EGFR), erb-B4, TGF-betaRI and II, Flt and Flk-1 and IGF receptor Ibeta, were found in epithelial cells and/or in some lymphoid cells. Fibronectin, laminin, collagen type IV and tenascin were found in stroma of the lymphoid tissue. Integrins such as alpha3beta1 and beta3, Thy-1, CD44 and VCAM-1 were also expressed in epithelial and/or lymphoid cells. These various proteins may interact and regulate the proliferation and cell attachment of both epithelial and lymphoid components in this unique tumor.

Citations

Mar 26, 2004·Auris, Nasus, Larynx·Kikuo SakamotoTadashi Nakashima
May 23, 2009·The Journal of Laryngology and Otology·K SakamotoT Nakashima
Jun 1, 2006·Journal of Applied Oral Science : Revista FOB·Patrícia Meira BentoLélia Batista de Souza
Nov 4, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jiri HozaIvo Starek
Mar 21, 2009·Clinical Chemistry·Mirco SchapherJohannes Zenk
Aug 14, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alexandra Corina FaurMarioara Cornianu
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ramaswamy Govindan

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