Abstract
The abilities of growth factors to cause normal cells to express the properties associated with transformed cells is discussed in specific reference to the oligodendrocyte-type-2 astrocyte (O-2A) progenitor cell. In the O-2A lineage, it has been possible to use growth factors and other defined molecules to induce or promote in normal cells all of the main properties of tumor cells, these being continued cell division in the absence of differentiation, more subtle modulations of self-renewal probabilities, promotion of cell migration and inhibition of programmed cell death. In addition to our studies on primary cells, our application to the growth of human tumor specimens of techniques utilized to study primary glial progenitor cells has allowed us to isolate a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated cells with features of precursor cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonst...Continue Reading
Citations
Mar 17, 2001·Nature Reviews. Genetics·E C Holland
Mar 29, 2002·Glia·Yuan Yuan WuMahendra S Rao
Jun 15, 2007·Journal of Neuro-oncology·Filip KramarPetr Kozler
Sep 19, 2012·Oncogene·B DikshitK Chosdol
Nov 5, 2014·Stem Cells Translational Medicine·Xianmin ZengMahendra Rao
Mar 17, 2000·Glia·J C LeeM S Rao
Jul 19, 2000·Journal of Neurophysiology·D R PiperM T Lucero
Apr 18, 2001·Current Opinion in Oncology·E C Holland
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·J HeK Hoang-Xuan
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Vasanth Kumar BhaskaraPhanithi Prakash Babu
Aug 31, 2002·Glia·Tatyana N IgnatovaDennis A Steindler
Sep 23, 2011·Journal of Translational Medicine·Sheng-Hua ChuPu-Cha Jiang
Jul 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Akira WatanabeHiroyuki Aburatani
May 9, 2003·Oncogene·Alessandro BeghiniLidia Larizza
Apr 8, 2006·Neuropathology and Applied Neurobiology·C ColinD Figarella-Branger
Apr 7, 2005·Glia·Patricia S RitchHarald Sontheimer
Sep 12, 2008·Acta Neuropathologica·Peter Canoll, James E Goldman
Jun 16, 2004·Journal of Neuroscience Research·Paul T MassaKaren Fecenko-Tacka
Aug 28, 1999·The Journal of Biological Chemistry·S E StringerJ T Gallagher
Feb 21, 2002·Journal of Neuropathology and Experimental Neurology·Marius Wernig, Oliver Brüstle
Dec 7, 2000·Cancer Genetics and Cytogenetics·X Mao, R A Hamoudi
May 17, 2005·Brain Research·Silva H HanissianJon H Robertson